基线BMI水平与MCI患者认知转归的相关性探讨

The correlation between the baseline BMI levels and cognitive outcomes in MCI patients

目的探讨基线BMI水平与MCI患者认知转归的相关性。方法入组2011年10月-2012年10月在上海市浦东新区周浦医院及同济大学附属东方医院神经内科门诊就诊的75例MCI患者,随访时间为(1.70±1.25)y。随访内容:蒙特利尔认知评估量表(MOCA)、简易智能精神状态检查量表(MMSE)、画钟试验(CDT)检查、基线资料以及相关临床资料。数据分析使用SPSS 19.0统计学软件包,P<0.05有统计学意义。随访结果 MOCA总分较基线增加2分或以上为认知功能好转(好转组);减少2分或以上为认知功能恶化(恶化组);增减少于2分为认知功能稳定(稳定组)。结果 MCI随访者中好转组30例,稳定组30例,恶化组15例。恶化组基线BMI<24 kg/m2者10例(66.67%),好转稳定组22例(36.67%),两组比较有统计学差异(P<0.05);影响因素分析基线BMI<24 kg/m2(%)的P值<0.05,有统计学意义。结论基线BMI<24 kg/m2与MCI患者认知恶化存在相关性,可以进一步扩大随访人数、延长随访时间,进而深入研究。

Objective To explore the correlation between the baseline BMI levels and cognitive outcomes in MCI patients. Methods 75 MCI outpatients in Shanghai Zhoupu Hospital in October 2011 to October 2012 were selected. Follow-up time is was 1. 70 ± 1. 25 years. The follow-up project included MOCA test,MMSE test,CDT test,baseline data and clinical data. Data analysis used SPSS 19. 0 statistical software package. P〈0. 05 was statistically significant. According to follow-up result,MOCA score dropped two points is was defined as cognitive deterioration. MOCA score increased two points is was defined as cognitive improvement. MOCA score changed within two points is was defined as stable group. Results There were 10 cases whose BMI 24 kg / m^2 in Worsen group（ 66. 67%）,and there were 21 cases whose BMI 24 kg / m^2 in stable group（ 36. 67%）. There were significant differences between the two groups（ P〈0. 05）. Influencing factors were analyzed. The the factor of baseline BMI 24 kg / m^2 was statistically significant（ P〈0. 05）. Conclusion There is a correlation between baseline BMI level and cognitive deterioration. We will expand the sample and extend the follow-up time to further clarify the correlation between the two in the future.