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白细胞介素35的在肿瘤发展中的作用 被引量:11

Current Research of the Roles of IL-35 in Tumor Progression
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摘要 白细胞介素(interleukin,IL)-35是IL-12细胞因子家族的新成员,自2007年发现以来IL-35很快成为了相关领域的研究热点。与IL-12家族的其他成员(IL-12、IL-23以及IL-27)相类似,IL-35也是由异源性的α链及β链组成,即p35和EBI3蛋白组成。目前的研究发现IL-35的功能主要表现在两个方面,一方面是IL-35在体内某些炎性疾病及自身免疫性疾病患者体内异常表达,IL-35在这些疾病的发生发展过程中起到重要作用。另一方面,IL-35在某些肿瘤中也表达异常,在肿瘤的发展过程中起到了重要作用。本文对IL-35的结构及信号通路进行了阐述,并总结了IL-35在肿瘤发展中的作用的最新研究进展。 Interleukin(IL)-35 is a new member of the interleukin-12 superfamily. Since its first report in 2007, IL-35 rapidly became a research highlight in the ifeld of immunology. Like other IL-12 superfamily members, IL-35 was a heterodimer which was composed of anαchain P35 and aβchain Epstein-Barr virus induced gene 3 (EBI3). Recent research work revealed two distinct roles of IL-35. Firstly, IL-35 is highly expressed in some kinds of inlfammatory diseases and autoim-mune diseases and plays import roles in the pathogenesis. Secondly, IL-35 is positively expressed in some cancers and plays some roles in the process of tumor progression. Here we demonstrate the structure and the signalling of IL-35. We reviewed the the roles of IL-35 in promoting tumor progression.
出处 《中国肺癌杂志》 CAS CSCD 北大核心 2016年第4期230-235,共6页 Chinese Journal of Lung Cancer
基金 国家自然科学基金项目(No.81501568)资助
关键词 白细胞介素 IL-35 肿瘤 肿瘤免疫 Interleukin Interleukin-35 Tumor Tumor immunology
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  • 1Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell, 2010, 140(6): 883-899.
  • 2Moor MM, Chua W, Charles KA, et al. Inflammation and cancer: causes and consequences. Clin Pharmacol -her, 2010, 87(4): 504-508.
  • 3Balkwill F, Mantovani A. Cancer and inflammation: implications for pharmacology and therapeutics. Clin Pharmacol Ther, 2010, 87 (4): 401-406.
  • 4Fox JG, Wang TC. Inflammation, atrophy, and gastric cancer. J Clin Invest, 2007, 117(1): 60-69.
  • 5Aggarwal BB, Gehlot E Inflammation and cancer: how friendly is the relationship for cancer patients? Curr Opin Pharmacol, 2009, 9(4): 351-369.
  • 6Balkwill F, Charles KA, Mantovani A. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell, 2005, 7(3): 211-217.
  • 7Valdivia-SilvaJE, Franco-BarrazaJ, Silva AL, et al. Effect of pro-inflammatory cytokine stimulation on human breast cancer: implications of chemokine receptor expression in cancer metastasis. Cancer Lett, 2009, 283 (2): 176-185.
  • 8Karin M. Nuclear factor-KB in cancer development and progression. Nature, 2006, 441 (7092): 431-436.
  • 9Apte RN, Voronov E. Is interleukin- 1 a good or bad guy in tumor immunobiology and immunotherapy? Immunol Rev- 2008, 222: 222-241.
  • 10Auron PE, Webb AC, Rosenwasser L J, et al. Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc Natl Acad Sci USA, 1984, 81(24): 7907-7911.

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