小细胞肺癌驱动基因研究进展

Advances on Driver Mutations of Small Cell Lung Cancer

小细胞肺癌是一类具有高度侵袭性的肺恶性肿瘤,预后极差,近30年来,其治疗策略无明显进展。积极研究小细胞肺癌分子生物学特征,并筛选潜在驱动基因,有助于为小细胞肺癌开拓新的治疗途径,改善疾病预后。本文将对小细胞肺癌驱动基因研究相关进展进行综述。

Small cell lung cancer （SCLC） is an aggressive tumor and prognosis remains dismal. Screening for the targetable driver mutations of this malignant tumor contributes to improve the therapeutic approaches and outcome. hTis re-view will report the advances on some latest driver mutations.