P53蛋白表达与晚期卵巢浆液性腺癌预后的相关性

Relationship between P53 Protein Expression and Prognosis of Advanced Ovarian Serous Adenocarcinoma

目的探讨P53蛋白表达与晚期卵巢浆液性腺癌临床病理特征及预后的相关性。方法应用免疫组织化学方法检测183例晚期卵巢浆液性腺癌患者肿瘤组织中P53蛋白的表达,探讨其与患者临床病理特征及预后的关系。结果62.8%的患者组织中存在P53蛋白表达。P53蛋白的过度表达与卵巢浆液性腺癌二级分级和初始治疗前血清CA125的升高呈正相关（P〈0.001,P=0.038）;单因素分析显示患者的预后与两级分级（P=0.007）、淋巴结转移（P=0.036）、术前CA125水平（P=0.002）及P53蛋白高表达（P〈0.001）相关,多因素分析提示国际妇产科联盟分期（P=0.038）、淋巴结转移（P=0.002）及P53蛋白高表达（P=0.001）是独立的预后影响因素。结论 P53蛋白的表达与晚期卵巢癌的预后密切相关,可作为预测卵巢癌预后的重要指标。

Objective To study the expression of P53 protein in the advanced ovarian serous adenocarcinoma and explore its potential correlation with the clinicopathological features and prognosis of ovarian cancer.Methods The immunohistochemical staining was used to detect the expression of P53 protein in 183 patients with advanced ovarian serous adenocarcinoma. The correlation of P53 protein with the clinicopathological features and its significance in the assessment of prognosis were explored. Results The P53 protein expression was positive in 62. 8% of the patients. Chi-square test showed that the overexpression of P53 protein was positively correlated with the elevation of serum CA125 and the two-tier grading of ovarian serous adenocarcinoma（ P 〈0. 001,P = 0. 038）. Univariate analysis suggested that the prognosis of patients was associated with two-tier grading（ P = 0. 007）,lymph node metastasis（ P = 0. 036）,preoperative serum CA125 level（ P = 0. 002）,and P53overexpression（ P 〈0. 001）. Multivariate analysis showed that the International Federation of Gynecology and Obstetrics stage（ P = 0. 038）,lymph node metastasis（ P = 0. 002）,and overexpression of P53（ P = 0. 001）were independent prognostic factors. Conclusion The P53 protein expression is closely related to the prognosis of advanced ovarian serous adenocarcinoma and can be used as an important indicator for predicting the prognosis.