血浆氧化型低密度脂蛋白检测在肾细胞癌诊治中的临床意义

The Clinical Value of Plasma Oxidized Low-density Lipoprotein in Renal Cell Carcinoma

[目的]评估血浆氧化型低密度脂蛋白(ox-LDL)检测在肾细胞癌诊疗中的临床意义。[方法]使用ELISA方法测定血浆ox-LDL浓度,研究对象包括84例来自复旦大学附属肿瘤医院的肾细胞癌患者以及对照人群(40名体检健康者)。[结果]肾细胞癌组血浆ox-LDL含量为9.28(7.93,10.93)ng/ml,显著性高于健康人群血浆ox-LDL含量7.23(6.43,8.00)ng/ml(P<0.05)。肾细胞癌患者手术治疗后血浆ox-LDL水平较术前有所下降。血浆ox-LDL与肿瘤大小相关;而恶性程度高的患者血浆ox-LDL较高。[结论]肾细胞癌患者血浆ox-LDL水平较健康者高,且ox-LDL水平与肿瘤大小和恶性程度密切相关。

[Purpose] To investigate the significance of Plasma Oxidized Low-density Lipoprotein（ox-LDL） in renal cell carcinoma.. [Methods] Plasma ox-LDL in 84 patients with renal cell carcinoma from Fudan University Shanghai Cancer Center and 40 samples from normal individuals as controls were detected by enzyme-linked immunosorbent assay. [Results] Plasma ox-LDL in renal cell carcinoma group [9.28（7.93,10.93）ng/ml ]was higher than that in healthy control group [7.23（6.43,8.00） ng/ml]（P〈0.05）. Plasma ox-LDL level of renal cell carcinoma decreased after surgery,and it correlated with tumor volume in patients with renal cell carcinoma. The level of plasma ox-LDL was elevated with the progression of renal cell carcinoma. [Conclusion] Plasma ox-LDL level in patient with renal cell carcinoma was at a higher level. Furthermore,the ox-LDL level is correlated with tumor volume and tumor malignancy.