从线粒体动力学角度探索肾脏病治疗新策略

New therapeutic strategy of kidney diseases from the perspective of mitochondrial dynamics

线粒体是真核生物细胞中一种高度动态变化的细胞器,通过不断的融合分裂,维持线粒体网络的稳态,线粒体的动态平衡对肾脏、心脏、骨骼肌等组织器官功能的维持起着至关重要的作用。线粒体动力学在肾脏疾病发生、发展过程中的作用尚未完全阐明,但越来越多的证据表明,线粒体动力学改变广泛参与急性肾衰竭和糖尿病肾病等肾脏疾病的病理变化过程,该文介绍了近年来线粒体动力学与肾脏疾病病理变化研究所取得的最新进展,并提出肾脏病防治的新策略。

Mitochondria,as a highly dynamic organelle existing in the eukaryocyte,is able to maintain the stabilization of mitochondrial network by constant fusion and fission. Mitochondrial dynamics equilibrium plays a crucial role in maintaining the function of tissues and organs,such as kidney,heart,skeletal muscle,etc. However,the mechanism underlying the effect of mitochondrial dynamics upon the incidence and progression of kidney diseases remains elusive. Accumulated evidence has demonstrated that the changes in mitochondrial dynamics are widely involved with the pathogenesis and development of acute renal failure,diabetic nephropathy and alternative renal diseases. In this paper,recent research progresses in terms of the association between mitochondrial dynamics and kidney diseases were summarized and reviewed,aiming to explore novel prevention and treatment of renal diseases.