分散固相萃取-液相色谱法测定食品纸包装材料中7种丙烯酸酯类化合物

Determination of Seven Acrylate Compounds in Food Packaging Paper Materials by Dispersive Solid-phase Extraction Coupled with HPLC

建立了一种简单、快速测定食品纸包装材料中7种丙烯酸酯类化合物（2-丙烯酸甲酯、2-丙烯酸乙酯、2-丙烯酸丁酯、2-丙烯酸辛酯、2-甲基-2-丙烯酸甲酯、甲基丙烯酸-2-羟乙基酯和2-甲基-2-丙烯酸辛酯）的分散固相萃取净化-液相色谱分析方法。样品以丙酮提取,混合吸附剂（10 mg多壁碳纳米管和50 mg硅藻土）分散净化后采用AQ C18液相色谱柱分离,紫外检测器检测。7种丙烯酸酯类化合物在0.10~100 mg/L范围内线性关系良好,相关系数均大于0.999,方法的检出限为0.027~0.066 mg/kg,回收率为83.9%~109%,日内精密度（n=6）为1.4%~5.5%,日间精密度（n=5）为4.7%~9.3%。该方法具有净化效果好、定量准确、灵敏快速的特点,适用于食品纸包装材料中7种丙烯酸酯类化合物的检测分析。

A simple and rapid method was developed for the determination of seven acrylates（methyl acrylate,ethyl acrylate,butyl acrylate,n-octyl acrylate,methyl methacrylate,2-hydroxyethyl methacrylate,and n-octyl methacrylate） in the paper materials used for food packaging by high performance liquid chromatography（HPLC） following dispersive solid phase extraction（d-SPE）.The paper sample was extracted with acetone under ultrasonication,and the extract was purified by a simple d-SPE using mixed adsorbents（10 mg of multi-walled carbon nanotubes and 50 mg of Celite（kieselguhr）.The purified extract was fractionated using AQ C18 column chromatography and the components were detected with an ultraviolet（UV） detector.The calibration curves of the seven acrylates were linear in the concentration range of 0.10~100 mg/L,with correlation coefficients above 0.999.The limits of detection（LODs） were in the range of 0.027–0.066 mg/kg;the mean recoveries of acrylates in spiked samples ranged from 83.9 to 109 %;the intra-day precisions（n = 6） and inter-day precisions（n = 5） were in the ranges of 1.4 to 5.5%,and 4.7 to 9.3%,respectively.The method developed in this study is sensitive and rapid and can be used for the purification and accurate quantitation of the acrylates It has application in the detection and analysis of the seven acrylates in paper materials used for food packaging.