米诺环素在皮肤科临床中的应用

Clinical application of minocycline in dermatology

米诺环素为半合成的四环素类抗生素,属于第二代四环素类抗生素,具有高效性和长效性,在四环素类抗生素中,抗菌作用最强。除了抗微生物作用,还有多种生物作用,如抗炎、抗凋亡、抑制蛋白水解,以及抑制血管生成和肿瘤转移等作用。临床上,四环素已被用于治疗各种皮肤疾病,如痤疮、酒渣鼻、大疱性皮肤病等。该文综述了米诺环素治疗皮肤病的新的进展,如治疗白癜风、色素性痒疹、自身免疫性大疱病、肉芽肿性疾病等,以期为一些皮肤病的治疗有药物禁忌时提供辅助或备选方法。

Minocycline is a second-generation, semi-synthetic tetracycline that has the strongest antibacterial effect in the tetracycline. In addition to anti-microbial effect, tetracyclines can exert a variety of biological actions that are independent of their anti-microbial activity, including anti-infl ammatory and anti-apoptotic activities, inhibition of proteolysis, inhibition of angiogenesis and tumor metastasis and so on. Clinically, tetracycline has been used to treat various skin diseases such as acne, rosacea, bullous skin diseases. This paper reviews new developments of the minocycline in the treatment of dermatosis, such as the treatment of vitiligo, prurigo pigmentosa, et al, so as to provide a reference for the treatment of some skin diseases by using minocycline.