胃癌组织中Ki67和TOPOⅡα的表达及其与临床病理参数的关系

Expression of Ki67T OPOⅡ alpha in gastric cancer tissue and its relationship with clinic pathological parameters

[目的]探讨胃癌组织中Ki67和TOPOⅡα的表达及其与临床病理参数的关系。[方法]选择2014年1月~2015年7月手术切除并经病理检查确诊的160例胃癌患者的石蜡包埋标本为研究对象,免疫组化法检测Ki67和TOPOⅡα在胃癌组织中的表达,并分析Ki67和TOPOⅡα与临床病理资料的关系。[结果]胃癌组织中Ki67大部分位于细胞核内,阳性表达率为78.13%;TOPOⅡα大部分为细胞核阳性,阳性表达率为63.13%。胃癌组织中Ki67和TOPOⅡα均与胃癌肿瘤病理分级、淋巴结转移、组织学分级显著相关,差异有统计学意义（P〈0.05）,且Ki67和TOPOⅡα在胃癌组织中的表达与临床病理参数呈正相关（r=0.521,P〈0.05）。[结论]胃癌组织中Ki67和TOPOⅡα的表达阳性率较高,Ki67和TOPOⅡα的表达与临床病理参数呈正相关。

[Objective]To study the expression of Ki67 TOPO Ⅱ alpha in gastric cancer tissue and its relationship with clinic pathological parameters.[Methods]The paraffin-embedded tissues were surgical resection from one hundred and sixty patients with gastric cancer patients confirmed by pathological examination from January 2014 to July 2015.The expression of Ki67 TOPO Ⅱ alpha in gastric cancer tissue was detected by immunohistochemical method.The correlation between Ki67 TOPO Ⅱalpha and clinical pathological data was analyzed.[Results]The expression of Ki67 in gastric cancer tissues was located in the nuclei,and the positive expression rate was 78.13%.The expression of TOPO Ⅱ alpha in gastric cancer tissues was located in the nuclei,and the positive expression rate was 63.13%.The Ki67 and TOPO Ⅱ alpha in gastric cancer tissue were related to gastric tumor pathological stage,lymph node metastasis and histological grading with statistically significant difference（P〈0.05）.The expression of Ki67 and TOPO Ⅱ alpha in gastric cancer tissues were positive correlation with clinic pathological parameters（r=0.521,P〈0.05）.[Conclusion]The positive rates of Ki67 TOPO Ⅱ alpha expression in gastric cancer tissue were higher,and the expression of Ki67 TOPO Ⅱ alpha in gastric cancer tissue was positive related to clinic pathological parameters.