前列环素合酶基因 rs5602多态性与中国汉族人群缺血性卒中的相关性

Correlation between prostacyclin synthase gene rs5602 polymorphism and ischemia stroke in Chinese Han population

目的：探讨前列环素合酶（prostaglandin I2 synthase, PGIS）基因 rs5602单核苷酸多态性与中国汉族人群缺血性卒中的相关性。方法纳入汉族缺血性卒中患者和健康对照者,采用基质辅助激光解吸电离飞行时间质谱法（ matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, MALDI TOF MS）检测 rs5602多态性。结果共纳入297例缺血性卒中患者（男性177例,女性120例）和291名同期体检的健康对照者（男性165名,女性126名）。缺血性卒中组男性TT 基因型（31．1%对43．6%；χ2=5．773,P =0．016）和 T 等位基因（56．8%对65．8%；χ2=5．793,P =0．016）分布频率均显著低于对照组男性,而女性则不然。多变量 logistic 回归分析显示,rs5602 TT 基因型是男性缺血性卒中的保护因素（优势比0．260,95%可信区间0．118~0．570；P =0．001）。结论在中国汉族人群中,PGIS 基因 rs5602多态性与男性缺血性卒中有关。

Objective To investigate the correlation between prostacyclin synthase （prostaglandin I2 synthase, PGIS） gene rs5602 single nucleotide polymorphism and ischemia stroke in Chinese Han population. Methods The patients with ischemia stroke and healthy controls in Chinese Han population were enroled. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry （MALDI TOF MS） was used to detect the rs5602 polymorphism. Results A total of 297 patients with ischemic stroke （male 177 and female 120） and 291 healthy controls （male 165, female 126） over the same period were enroled. The frequencies of TT genotype （31. 1% vs. 43. 6% ; χ2 = 5. 773, P = 0. 016） and T alele （56. 8% vs. 65. 8% ; χ2 = 5. 793, P = 0. 016） in the male patients with ischemic stroke were significantly lower than those in the male healthy controls. Multivariate logistic regression analysis showed that the rs5602 TT genotype was a protective factor for ischemic stroke in male （odds ratio 0. 260, 95% confidence interval 0. 118-0. 570; P = 0. 001）. Conclusions PGIS gene rs5602 polymorphism is associated with ischemic stroke in male in Chinese Han population.