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p53突变蛋白对人肺腺癌细胞中E-cadherin的表达调控及细胞迁移的影响 被引量：2

Mutant p53 down-regulates E-cadherin expression in human lung adenocarcinoma cells to enhance cell migration
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摘要 在人肺肿瘤细胞H1299中稳定表达含R273H点突变的p53蛋白(p53-R273H),观察到细胞中E-cadherin mRNA和蛋白水平下调,同时细胞迁移能力增强.免疫荧光方法检测发现p53-R273H显著降低E-cadherin在肿瘤细胞间的表达.这些结果表明p53-R273H突变蛋白具有下调E-cadherin基因的表达和促使肿瘤细胞迁移的新功能. Stably-expressing p53-R273 Hin H1299human lung cancer cells promoted cell migration and concomitant of down-regulated E-cadherin expression.Immunofluorescent staining showed reduced Ecadherin at cell-cell junction.Together,these data suggest that mutant p53-R273 H protein acquires a new activity in down-regulating E-cadherin expression and promoting cancer cell migration.
作者 万杨 吕涛 肖智雄
机构地区 四川大学生命科学学院生长代谢与衰老研究中心
出处 《四川大学学报（自然科学版）》 CAS CSCD 北大核心 2016年第3期657-663,共7页 Journal of Sichuan University(Natural Science Edition)
基金 国家自然科学基金(31171362 31170729)
关键词 肿瘤细胞 p53-R273H E-CADHERIN 细胞迁移 Cancer cell p53-R273H E-cadherin Migration
分类号 Q279 [生物学—细胞生物学]
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参考文献26

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四川大学学报（自然科学版）
2016年 第3期

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