影响小儿癫痫持续状态近期疗效的因素

Influential Factors Concerning Short-Term Efficacy of Child Epilepsy Status Epilepticus

目的:探讨影响小儿癫痫持续状态(SE)近期疗效的因素。方法:104例SE住院治疗患儿,按性别、发病年龄、病因、诱因、发作类型、控制时间及治疗方案和相关检查(脑电图、头颅CT及头颅MRI)结果进行分组,采用χ2检验分析不同分组SE患儿出院时的近期治疗效果,分析影响SE患儿近期治疗的因素。结果:各年龄组SE患儿的病因多为癫痫,惊厥性癫痫持续状态(CSE)病因亦为癫痫(68.48%),以全身性CSE为主(91.3%);非惊厥性癫痫持续状态(NCSE)病因多为颅内感染(50%);按性别、发病年龄、病因、诱因、临床发作类型,头颅CT、头颅MRI及脑电图结果分组,各分类依据的SE患儿组间近期疗效比较,差异无统计学意义(P>0.05),按治疗方案分组的SE患儿的近期疗效比较,咪达唑仑组治疗有效率(100%)高于非咪达唑仑组有效率(84.09%),差异有统计学意义(P<0.05)。结论:治疗方案是影响SE近期疗效的因素。

Objective： To investigate influential factors affect child epilepsy status epileptius（ SE）.Methods： 104 SE children patients were grouped according to gender,age of onset,etiological factors,inducement,clinical seizure types and the relevant factors impacting the short-term effects of status epilepticus in children（ EEG,skull CT and skull MRI）. χ2was adopted to test short-term efficacy of different groups SE children patients,and then analyzing influential factors. Results： Epilepsy was the main etiology factors for different groups SE children patients,CSE etiology factor was also epilepsy（ 68. 48%）,featured with full body CSE（ 91. 3%）; NCSE etiology factor was mainly intracranial infection（ 50%）; grouped according to gender,age of onset,etiology factors,clinical seizure types,skull CT,skull MRI and EEG,short term efficacy comparison was made,differences showed statistical significance（ P〈 0. 05）; short-term efficacy according to treatment categorization showed that midazolam group TER therapeutic efficiency ratio（ 100%） was higher than non-midazolam group（ 84h09%）,differences were statistical significant（ P〈 0. 05）. Conclusion： The difference of treatment plans is the factor affecting the short-term efficacy of SE.