中国大陆第三例输入性寨卡病毒病病例调查分析

Survey of the third Zika virus disease case in the mainland of China

目的对中国大陆第三例输入性寨卡病毒病病例进行调查分析，为防控寨卡病毒病提供工作经验和参考依据。方法对中国大陆第三例输入性寨卡病毒病病例的临床表现、实验室检测、诊疗和流行病学调查进行描述性分析。结果2016年2月19日，经中国CDC有关专家复核和专家会诊，我国义乌市确诊1例从斐济、萨摩亚旅游归来的输入性寨卡病毒病病例，病例曾在萨摩亚有蚊虫叮咬史。病例2月14日发病，15日出疹，16日出现结膜炎，16日收住入院，17日体温正常，19日皮疹消失，20日结膜炎消失。血液中寨卡病毒核酸检测阳性持续仅3d，血液核酸检测阴性4d后尿液仍可检测到核酸阳性。结论该病例寨卡病毒病症状典型，早期可采集病例血液进行寨卡病毒核酸检测，体温正常后应采集尿液进行寨卡病毒核酸检测。

Objective To evaluate the performance of Zika virus （ZIKV） disease prevention and control. Methods Descriptive epidemiological analysis was conducted on the clinical manifestations, laboratory detection results and disease progression of the third imported ZIKV disease case in the mainland of China. Results On 19 February 2016, a ZIKV disease case was confirmed in Yiwu, Zhejiang province, which was the third imported case of ZIKV disease confirmed by China CDC laboratory and expert consulting. The patient just had a travel to Fiji and Samoa and had mosquito bite history in Samoa. The patient was hospitalized on 16 February after the onset on 14 February and the eruption on 15 February. The body temperature of the patient became normal on 17 February, the rash disappeared on 19 February and the conjunctivitis resolved on 20 February. The positive detection of the viral nucleic acid in blood was only for 3 consecutive days, and the viral nucleic acid could be detected in urine even after negative detection in blood for 4 days. Conclusion The symptoms of the patient were typical. ZIKV can be detected by using blood sample in early phase, but after body temperature become normal, the virus can be detected in urine.