连续性血液净化不同剂量对重症急性肾损伤患者预后的影响

Effect of Different Doses of Continuous Blood Purification on the Prognosis of Patients with Severe Acute Kidney Injury

目的探索适用于中国重症急性肾损伤患者的连续血液净化治疗的最佳治疗剂量。方法选择2010年11月至2014年2月期间在广东省人民医院就诊的患者,通过纳入和排除标准选择符合入组标准的重症急性肾损伤患者。入选患者根据随机数字表随机分为高剂量[35 m L/(kg·h)]组和低剂量[25 m L/(kg·h)]组。观察终点指标为随机分组后14天、28天、90天的生存率及肾脏的恢复情况。结果符合纳入和排除标准的患者共103例,高剂量组52例,低剂量组51例。Kaplan-Meier生存分析结果显示,高剂量组和低剂量组患者的14天、28天以及90天生存率差异均无统计学意义(P>0.05)。结论增加连续性血液净化治疗剂量并不能改善急性肾损伤患者的临床预后,建议将重症急性肾损伤黄种人患者的标准剂量定为25 m L/(kg·h)。

Objective To explore the suitable dose of CBP in China S-AKI the best treatment. Method Patients with S-AKI in Guangdong General Hospital during 2010 November to 2014 February for CBP treatment were selected. All patients were recruited randomly divided into 3 groups. Results 103 patients were randomly divided into high dose group and low dose group. Kaplan-Meier survival analysis showed that there was no significant difference between the survival rate of high dose group and that of low dose group in 14 days,28 days and 90 days（P〉0.05）. Conclusion Increasing dose of CBP may not improve the clinical prognosis of patients with AKI.