低分子肝素钠治疗肺心病并心力衰竭效果观察

Effect of low molecular heparin sodium in the treatment of pulmonary heart disease combined with heart failure

目的观察低分子肝素钠治疗肺心病并心力衰竭的临床效果。方法选取我院2013年7月~2015年9月收治的肺心病并心力衰竭患者89例,按入院时间先后分为对照组（44例）、观察组（45例）,给予对照组综合治疗,给予观察组以对照组为基础加用低分子肝素钠治疗,对比两组治疗前后的实验室指标、临床效果及不良反应发生率。结果治疗后两组血浆粘度、全血粘度、红细胞数、红细胞压积、纤维蛋白原定量及凝血酶原时间较治疗前明显改善,其中观察组改善程度优于对照组（P〈0.05）。观察组总有效率93.33%（42/45）明显高于对照组的79.55%（35/44）,差异有统计学意义（P〈0.05）。观察组并发症发生率6.67%（3/45）显著低于对照组的27.27%（12/44）,差异有统计学意义（P〈0.05）。结论低分子肝素钠治疗肺心病并心力衰竭,疗效确切,改善心功能与各项指标,安全性高,值得推广。

Objective To explore the clinical effect of low molecular heparin sodium in the treatment of pulmonary heart disease combined with heart failure. Methods 89 patients with pulmonary heart disease and heart failure who were in our hospital from July 2013 to September 2015 were divided into control group（44 cases） and observation group（45 cases） according to their admission time. The control group received complex treatment, and the observation group was treated with low molecular heparin sodium based on complex treatment. The laboratory indices, clinical effects, and adverse reaction incidences before and after treatment of the two groups were compared. Results After treatment, the plasma viscosities, whole blood viscosities, red blood counts, hematokrits,fibrinogen quantities and prothrombin time in the two groups were better than those before intervention, and the improvements in the observation group were superior than those of the control group（P〈0.05）.The total effective rate of the observation group was 93.33%（42/45）,which was obviously higher than the 79.55%（35/44） of the control group, the difference was statistically significant（P〈0.05）.The complication rate of the observation group was 6.67%（3/45）,which was obviously lower than the 27.27%（12/44）of the control group, the difference was statistically significant（P〈0.05）. Conclusion The low molecular heparin sodium has a clear effect in the treatment of pulmonary heart disease combined with heart failure, which can improve the patients＇ heart functions with high safety.It is worthy of being promoted.