支气管哮喘急性发作期不同吸入给药方法疗效观察

Observation on the effect of different ways of inhalation for acute attack of bronchial asthma

目的比较两种不同吸入给药方法治疗儿童哮喘急性发作时的疗效。方法 2012年1月至2015年1月荆州市妇幼保健院儿科收治支气管哮喘中度急性发作患儿84例,随机分为观察组和对照组各42例。观察组选用沙丁胺醇气雾剂加储雾罐吸入,对照组将沙丁胺醇溶液加入空气压缩泵雾化吸入,比较两组患儿急性发作缓解速度及疗效、不良反应。结果两组经不同初始治疗给药后60min时临床疗效比较,两组总有效率比较差异无统计学意义(P>0.05)。两组治疗后咳嗽、气喘、哮鸣音均消失,两组比较差异无统计学意义(P>0.05)。两组各有1例患儿出现心悸,未发现其他明显不良反应。结论沙丁胺醇气雾剂加储雾罐吸入与其溶液加入空气压缩泵雾化吸入均能迅速缓解哮喘急性发作患者的临床症状,医疗单位可以根据自身情况酌情选用。

Objective To compare the effect of two ways of inhalation in the treatment of children with acute attack of asthma.Methods A total of 84 children with acute attack of bronchial asthma of moderate stage in Jingzhou Women and Children Hospital from Jan.2012 to Jan.2015 were included in the study and they were divided into two groups：observation group and control group,with 42 cases in each group.Salbutamol aerosol was put into spacer for inhalation for the observation group,while salbutamol solution was put into air-compression pump for nebulized inhalation in the control group.Compare the relief time,effect and adverse reactions between the two groups.Results After 60 min of treatment,the total effective rate had no statistical difference between the two groups（P0.05）.Cough,wheezing and wheezing rales disappeared after treatment in both groups,the difference being of no statistical significance（P0.05）.There was one case of palpitation respectively in each group,but there was no other obvious adverse reaction.Conclusion Both of the two ways of treatment mentioned above can rapidly relieve the clinical symptoms of patients with acute attack of asthma,therefore the medical institutions can choose either of them based on their own situations.