基于复杂网络分析国医大师周仲瑛治疗类风湿关节炎的用药经验

Prescription Experiences of Professor ZHOU Zhong-ying in Treating Rheumatoid Arthritis Based on Complex Networks Analysis

目的:利用复杂网络分析方法,总结国医大师周仲瑛治疗类风湿关节炎(rheumatoid arthritis,RA)的临证用药规律。方法:纳入符合类风湿关节炎诊断标准患者166例,845诊次,将全部诊疗信息录入结构化临床信息采集系统,应用"名老中医临床信息采集系统"的数据库进行复杂网络分析,对国医大师周仲瑛教授治疗RA的核心药物及配伍规律进行数据挖掘。结果:周仲瑛教授治疗RA的核心药物有青风藤、地黄、黄芪、鬼箭羽、防己、赤芍、炙僵蚕、炙全蝎、制南星、炙桂枝、黄柏等,对RA的治疗祛风除湿、清热通络、温经散寒、化痰祛瘀、扶正补虚为主。结论:运用复杂网络分析方法的研究结果,充分反映了周仲瑛教授对RA病机的认识、辨证思路及组方用药特色。

Objective： To investigate the prescription experiences of professor ZHOU Zhong-ying in treating rheumatoid arthritis（ RA） based on complex networks analysis. Method： Totally 166 RA cases（ 845encounters） were selected as the clinical cases,and their diagnosis and treatment information was transformed into structured electronic medical record system. Then the complex network method was used with ‘Prestigious Traditional Chinese Medicine Specialists Clinical Information Collection System＇,to dig out the core herbs and prescription rules of professor ZHOU Zhong-ying for treating RA. Result： The core herbs used by professor ZHOU Zhong-ying for RA included Sinomenii Caulis, Rehmanniae Radix, Astragali Radix, Euonymus Alatus,Stephaniae Tetrandrae Radix, Paeoniae Radix Rubra, Bombyx Batryticatus, Scorpio, Arisaema Cum Bile,Cinnamomi Ramulus,Phellodendri Chinensis Cortex,etc. The main therapy for RA was based on dispelling wind and eliminating dampness, clearing heat and dredging collaterals, warming channel and expelling cold,dissipating phlegm and removing blood stasis, strengthening the body resistance and tonifying deficiency.Conclusion： The results of complex network analysis fully reflected professor ZHOU Zhong-ying＇s clinical perceive of pathogenesis,syndrome differentiation and medication features of RA.