情绪对焦虑症患者认知功能的影响

Effect of emotion on cognitive function in patients with anxiety

目的探讨情绪对焦虑症患者认知功能的影响。方法选取2013年1月-2015年5月海南省儋州市农垦那大医院收治的98例首发焦虑症患者为研究对象纳入观察组,并选择98名健康成人作为对照组,以汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)及蒙特利尔认知评估量表(Mo CA)分别评估两组的焦虑、抑郁情绪及认知功能,比较两组的基线资料及HAMA、HAMD和Mo CA评分,采用Pearson相关分析和多重线性回归分析探讨焦虑症患者发生认知功能损害的影响因素。结果观察组的HAMA和HAMD评分显著高于对照组(P<0.05)。观察组Mo CA的视空间与执行功能、注意力、抽象及定向等方面的评分及总分均显著低于对照组(P<0.05)。Pearson相关分析结果表明观察组患者的Mo CA总分与HAMA评分呈负相关(r=-0.217,P=0.032),与HAMD评分呈负相关(r=-0.228,P=0.024)。多重线性回归分析结果表明年龄、HAMA及HAMD评分进入最后的方程中,3者均与Mo CA总分呈负相关(P<0.05)。结论焦虑症患者的焦虑及抑郁情绪的严重程度与认知功能损害有关,且抑郁情绪可能是其主要因素。

Objective To study the effect of emotion on cognitive function in patients with anxiety. Methods From January 2013 to May 2015, 98 first-episode patients with anxiety were enrolled as observation group, and 98 normal controls were investigated as control group. Hamilton anxiety scale（HAMA）, Hamilton depression scale（HAMD）, and Montreal cognitive assessment scale（MoCA） were performed to evaluate anxiety, depression, cognitive function respectively. Baseline data and scores of HAMA, HAMD, MoCA were compared between two groups. Pearson correlation analysis and multiple linear regression analysis were used to explore the influence factors of cognitive impairment for patients with anxiety. Results The scores of HAMA and HAMD in observation group were significantly higher than that in the control group（P〈0.05）. The scores of visual space and executive function, attention, abstraction,directional and total score of MoCA in the observation group were significantly lower than that in the control group（P〈0.05）. Pearson correlation analysis showed that MoCA total score was negatively correlated with HAMA score（r = 0.217, P = 0.217 0.05） and HAMD score（r = 0.228, P = 0.228 0.05） in observation group. Multiple linear regression analysis results showed that age, HAMA and HAMD scores were enrolled for the final equation, and they all had negative correlation with MoCA total score（P〈0.05）. Conclusions The severity of anxiety and depression in patients with anxiety are associated with cognitive impairment, and depression may be the main factor.