MCM-41型介孔纳米材料对氧氟沙星的负载及体外释放

Drug loading and in vitro release of ofloxacin from MCM-41 type mesoporous silica nanomaterials

虽然氧氟沙星抗菌谱广,抗菌作用强,在人医及兽医临床上被广泛地应用,但是其生物半衰期短,给临床用药带来不便。为了开发长效氧氟沙星制剂,本研究以高比表面积、比孔容的MCM-41型介孔二氧化硅纳米材料为载体,制得氧氟沙星纳米药物OFX@MSN。并分别通过扫描电镜、透射电镜,氮气吸附-脱附、傅里叶红外等手段对载药前后的纳米粒结构进行了结构确证,证明氧氟沙星载入到介孔二氧化硅的孔洞中形成平均直径约为100nm的分散球状粒子。体外试验显示氧氟沙星的释放时间可以持续3d之久,从而有效维持平稳的血药治疗浓度,减小注射次数。

Ofloxacin is widely used in clinic.However,ofloxacin is inconvenience in clinical medication,because of its broad antimicrobial spectrum,strong antibacterial activity,and short biological half-life.In this study,ofloxacin nanoparticles（OFX@ MSN）was prepared with synthesized MCM-41 type mesoporous silica nanoparticles（MSN）which possesses the characteristics of high surface area,total pore volume and uniform mesoporous structure.Both structures of MSN and OFX@MSN were characterized by scanning electron microscopy,transmission electron microscopy,nitrogen adsorption-desorption and Fourier transform infrared.The results of in vitro studies showed that the release time of ofloxacin lasted for 3days from ofloxacin nanoparticles（OFX@MSN）,which could effectively maintain blood ofloxacin concentration,and reduce the number of injections.