胎动不安患者不同妊娠时间体内雌、孕激素变化对妊娠结局的影响

Effects of Estrogen and Progesterone Change on Pregnancy Outcome at Different Pregnancy Time Points in Fetal Irritability Patients

目的：通过体内雌、孕激素及血HCG检测,找到一种简单易行且行之有效的判断患者预后的方法。方法：随机选择100例胎动不安患者和50例正常妊娠者,在各组间不同时间段测定血清HCG、雌二醇以及孕酮值,绘制变化曲线,将胎动不安流产与保胎成功的患者之间拟合曲线相互比较,胎动不安流产与保胎成功的患者分别与正常妊娠相互比较,从而找到血清HCG、雌二醇以及孕酮值的变化对不同妊娠结局是否有预测作用。结果：不同妊娠时间,胎动不安患者发生流产的患者与得以继续妊娠的患者之间及正常妊娠患者之间,血清HCG及E2在变化趋势上存在明显差异。结论：妊娠7周时无论是HCG和E2在保胎成功和失败的患者间存在明显的分界点,提示我们在早期确认宫内妊娠后,在7~8周之间测激素水平预测胚胎发育正常与否是很必要的。

Objective： By estrogen and progesterone and HCG blood examination,to find out a simple and effective method to determine the prognosis of patients. Methods： We randomly selected 100 cases of fetal irritability patients and50 normal pregnancy patients. Measure serum HCG,estradiol and progesterone values of the groups in different time periods and then draw the curves. The fetal irritability abortion and tocolysis success were compared to find out the changes in serum HCG,estradiol and progesterone. Results： Serum HCG and E_2 had significant differences in the change between fetal irritability abortion,continued pregnancy patients and normal pregnancy according to different pregnant time. Conclusion： After 7 weeks of pregnancy,both HCG and E_2 have obvious demarcation point between success and failure in patients,pointing out at an early stage that we confirm the intrauterine pregnancy. During 7 to 8 weeks for pregnancy,it is necessary to measure the hormone levels in patients to predict the normal embryonic development.