银杏叶制剂对全麻下非心脏术后老年患者认知功能恢复的影响

Effects of Ginkgo Biloba on Cognitive Function under General Anesthesia in Elderly Patients after Noncardiac Recovery

目的:研究分析在老年患者全麻非心脏手术围术期中,使用银杏叶制剂治疗对其认知功能恢复造成的影响。方法:在医院实行非心脏手术的老年患者中选取70例作为研究对象,将其按照随机性分为对照组与观察组,各35例。对照组患者服用安慰片剂,观察组患者服用银杏叶片,两组患者术中均实施静吸复合全麻,比较两组术后1、7 d的POCD发生情况以及术前、术后1和7 d的MMSE评分。结果:术后1、7 d,两组患者的POCD发生率对比,以及两组患者术后7 d的MMSE评分与术前比较,差异不存在统计学意义(P>0.05)。观察组合并Ⅱ型糖尿病患者术后1 d的POCD发生率,显著低于对照组;术后1 d,观察组合并Ⅱ型糖尿病患者MMSE评分均低于术前与对照组,差异存在统计学意义(P<0.05)。结论:对老年全麻非心脏手术患者使用银杏叶制剂,对患者认知功能恢复的影响与安慰剂无显著差异;但对合并Ⅱ型糖尿病患者使用银杏叶制剂,对患者认知功能恢复的影响小于安慰剂,可推广应用与合并Ⅱ型糖尿病患者全面非心脏手术临床中。

Objective： To analyze the effect of Ginkgo biloba on cognitive function under general anesthesia in elderly patients undergoing noncardiac surgery. Methods： In our hospital,70 cases of elderly patients with noncardiac surgery were chosen as research subjects and were divided into two groups according to the random number,30 cases in each. The control group＇s patients took placebo tablet and the observation group＇s took Ginkgo biloba. Patients in both groups were given inhalation anesthesia. Compare POCD incidence 1 d and 7 d after operation and MMSE score before and 1 d and 7d after operation. Results： POCD incidence 1 d and 7 d after operation and MMSE score 7 d after surgery of the two groups were not statistically significant（ P〉0. 05）. Observation group＇s POCD of patients complicated with typeⅡ diabetes 1 d after operation was significantly lower than the control group＇s. MSE scores 1 d after operation were lower than those before operation and the control group＇s. The difference was statistically significant（ P〈0. 05）. Conclusion For elderly patients with non- cardiac surgery under general anesthesia,Ginkgo biloba has the impact on the recovery of cognitive function with no significant difference to placebo. However,for patients with type Ⅱ diabetes,the impact of Ginkgo biloba on the recovery of cognitive function in patients is less than that of the placebo. It could be applied in comprehensive noncardiac surgery complicated with type Ⅱ diabetes.