摘要
近年来的研究认为癌症是一种基因疾病,遗传性或获得性基因缺陷可导致癌症的发生和发展。因而,基因检测技术在妇科肿瘤的筛查中显得尤为重要。目前,人乳头瘤病毒(HPV)检测已在宫颈癌筛查中广泛应用,对于遗传性卵巢癌和子宫内膜癌高危群体,也可通过检测BRCA1/2和MLH1/MSH2突变进行高危人群风险分层。
Cancer is considered a genetic disease.In- herited or acquired genetic disorders are involved in the malignant transformation and progression of＇tumors. In gynecologic oncology, genetic testing has captured global attention, especially in tumor screening.Currently, HPV testing plays an essential role in cervical cancer screening; the detection of BRCA 1/2 and MLH1/ MSH2 mutations has been strongly recommended to stratify patients who have a high risk of developing ovarian cancer and endometrial cancer, respectively.
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2016年第5期409-413,共5页
Chinese Journal of Practical Gynecology and Obstetrics
关键词
基因检测技术
妇科恶性肿瘤
筛查
genetic testing
gynecologic malignan-cies
screening
