镍铬合金烤瓷冠和纯钛烤瓷冠对龈沟液中TNF-α和MMP-8水平指标的变化影响研究分析

Analysis of the influence of nickel-chromium alloy and titanium PFM crown on the TNF- α and MMP-8 level in gingival crevicular fluid

目的研究分析镍铬合金烤瓷冠和纯钛烤瓷冠对龈沟液中TNF-α和MMP-8水平指标的变化影响。方法选取本院2012年2月到2015年2月收治的行后牙种植体冠修复患者62例,共62枚试牙,所有患者后牙上部结构采用金属烤瓷冠修复,根据烤瓷内冠材料不同分为2组,即实验组1行镍铬合金烤瓷冠治疗,实验组2行纯钛烤瓷冠治疗,各31枚。两组分别在修复前和修复后8个月行临床指标、PISF量、MMP-8总量、TNF-α含量检测并进行比较。临床检查指标主要有菌斑指数、牙跟跟沟深度(GCD)、牙跟出血指数(SBI)。结果本实验结果显示,采用镍铬合金烤瓷冠修复后的8个月检测指标中,对牙跟跟沟深度(GCD)、牙跟出血指数(SBI)≥2频率具有一定的影响,同时明显增加修复后患牙PISF量、TNF-α含量及MMP-8含量。结论采用镍铬合金烤瓷冠修复后对种植体周组织影响比较大,而纯钦烤瓷冠修复对种植体影响很小,适合临床医师广泛应用。

Objective To study the influence of nickel-chromium alloy and titanium PFM crown on the TNF- α and MMP-8 level in gingival crevicular fluid（GCF）. Methods From February 2012 to February 2015 in our hospital, 62 patients treated with Porcelain-Fused-to-Metal crown were selected, a total of 62 teeth. According to the material inside the porcelain crown, they were divided into two groups. In the group A, nickel-chromium alloy crown was applied, and in the group B, titanium crown was applied, 31 cases in each group. Before the repair and 8 months after restoration, the clinical indicators, PISF, MMP-8 and TNF-α were detected and compared. Clinical examination index included the plaque index, gin-gival crevicular depth（GCD）, sulcus bleeding index（SBI）. Results The GCD and SBI 8 months after restoration in the group A were more influ-enced than than that in the group B. The levels of PISF, MMP-8 and TNF-α in group A were more increased than that in the group B. Conclusion Compared with the nickel-chromium alloy-porcelain crown, the titanium crown had little influence on the peri-implant tissues.