HMGB-1与炎症研究进展

Research advances of HMGB- 1 in inflammation

HMGB-1是一种高度保守的DNA结合蛋白,与基因修复及转录调控密切相关。但HMGB-1生成细胞主动分泌和被动释放到细胞外的HMGB-1却是一种重要的晚期炎症递质,具有较强的致炎活性。研究显示:HMGB-1在炎症,特别是重症炎症及炎症的慢性化病理进程中起着重要作用;抑制HMGB-1的活性及分泌或下调其基因表达被用来研究降低炎症反应的瀑布效应;监测HMGB-1可为重症炎症的临床诊断、治疗和预后判断的新靶标。本文扼要综述了近年炎症递质HMGB-1与炎症的研究进展。

HMGB1 is a highly conserved DNA binding protein and closely related to gene repairment and transcription regulation. But the extracellular HMGB1 secreted actively and released passively by the HMGB- 1-producing cells is an important terminal inflammatory mediator with strong inflammatory activity. Studies have shown that the extracellular HMGB- 1 plays an important role in the process of the pathological physiology in the inflammation,especially in severe and chronic inflammation. Inhibiting its activity and secretion and cutting their gene expression are used to investigate the cascade effects of suppressing inflammatory reaction. Detecting HMGB- 1 provides a new target for clinical diagnosis,treatment and prognosis judgment of severe inflammation. This review briefly summarized the advanced studies about HMGB- 1 as an inflammatory mediator in recent years.