鼻用糖皮质激素结合鼻腔冲洗治疗变应性鼻炎的疗效观察

Curative observation on allergic rhinitis treated by intranasal corticosteroids combined with nasal irrigation

目的:观察鼻用糖皮质激素结合鼻腔冲洗对变应性鼻炎(AR)的治疗效果。方法:将273例中-重度持续性AR患者随机分为3组,使用3种不同的治疗方案治疗12周,并于治疗前及治疗后4、8、12周采用视觉模拟量表、鼻结膜炎相关生活质量问卷以及症状评分与鼻内镜检查评分,评估患者治疗前后的病情变化并进行统计学分析。结果:鼻用糖皮质激素结合生理盐水鼻腔冲洗治疗AR的疗效优于单用鼻用糖皮质激素的疗效(P>0.05),且其疗效等同于鼻用糖皮质激素联合口服抗组胺药的疗效。结论:长期应用鼻用糖皮质激素结合生理盐水鼻腔冲洗能够有效控制和缓解中-重度持续性AR的临床症状,并能改善患者的生活质量,是单一使用鼻用糖皮质激素疗效不佳患者的可取选择。

Objective：To observe the effect of normal saline with intranasal corticosteroids in the treatment of allergic rhinitis（AR）.Method：Two hundred and seventy-three outpatients with severe persistent allergic rhinitis were participated in this study.All patients were randomly divided into three groups,and were treated for 12 weeks using three different therapies,respectively.Symptom assessment of each patient were performed before treatment,4weeks,8weeks,and 12 weeks after treatment,respectively.The content of symptom assessment includes visual analogue scale,rhinoconjunctivitis quality of life questionnaire,symptoms scores and endoscopy examination scores.Result：Efficacy of intranasal corticosteroids combined with normal saline nasal irrigation in the treatment of AR is better than that of intranasal corticosteroids only,and is almost equivalent to intranasal corticosteroids combined with antihistamines.Conclusion：Long-term application of intranasal corticosteroids in combination with normal saline irrigation can effectively control and mitigate symptoms of severe persistent AR patients,and improve the patient＇s quality of life.This combination therapy is a better choice for the patient who is not satisfied with the single use of intranasal corticosteroids.