特异性免疫治疗对变应性鼻炎患者心理和生活质量影响的研究

Effect of specific immunotherapy on the psychological health level and quality of life in patients with allergic rhinitis

目的:研究特异性免疫治疗对变应性鼻炎患者心理健康状况和生活质量的影响;方法:对97例确诊为中重度持续性变应性鼻炎的患者进行特异性免疫治疗,分别在治疗前和治疗6、12个月后进行症状自评量表(SCL-90)和鼻结膜炎生活质量问卷(RQLQ)评定。结果:变应性鼻炎患者在治疗6、12个月后测的SCL-90总分、躯体化、强迫、焦虑、抑郁、恐怖因子分明显降低,与治疗前相比差异有统计学意义(P<0.05);在治疗6、12个月后生活质量总分及各分量表得分明显下降,与治疗前相比差异有统计学意义(P<0.05)。结论:特异性免疫治疗作为一种病因治疗,可有效改善变应性鼻炎患者的临床症状,从而使患者的心理健康状况和生活质量得到改善。

Objective：To study the effect of specific immunotherapy on the psychological health level and quality of life in patients with allergic rhinitis（AR）.Method：Selected 97 cases diagnosed as moderate to severe persistent AR patients,were treated with specific immunotherapy for one year.All patients received the evaluation with symptom check list 90（SCL-90）and rhinoconjunctivitis quality of life questionnaire（RQLQ）before specific immunotherapy,six,and 12 months after specific immunotherapy.Result：The total scores,scores of somatization,obsessive,anxiety,depression and phobia in SCL-90 of AR patients after 12 months treatment were significantly lower than that before treatment（P〈0.05）.Total score of quality of life and subitem score in RQLQ of AR patients after 12 months treatment were obviously lower than that before treatment（P〈0.05）.Conclusion：Specific immunotherapy can effectively alleviate the clinical symptoms and improve psychological health level and quality of life of AR patients.