宁夏地区回汉人群变应性鼻炎患者血清中IL-4浓度与微量元素水平的相关性研究

The relationship between IL-4 and trace elements in patients with allergic rhinitis of hui and han populations in Ningxia

目的:研究宁夏地区回汉人群变应性鼻炎(AR)患者血清中微量元素与IL-4浓度的相关性。方法:以260例AR患者为AR组(回族130例,汉族130例);设正常对照组260例(回族130例,汉族130例)。采用ELISA法和电感耦合等离子体原子发射光谱法(ICP-AES)分别检测520例样本血清中IL-4的浓度及Fe、Zn、Mn、Ni、Se的含量,并分析回汉人群AR患者微量元素水平与IL-4之间的相关性。结果:1回族和汉族AR患者血清IL-4的含量均高于对照组(P<0.05);2回族AR患者血清Zn、Se的含量低于对照组,Ni高于对照组(P<0.05);汉族AR患者Zn低于对照组,Ni含量高于对照组(P<0.05);3AR组血清IL-4水平与Ni值呈正相关(r=0.671,P<0.01);IL-4水平与Zn值呈负相关(r=-0.819,P<0.01)。结论:宁夏地区回汉人群AR患者血清中IL-4浓度与Zn、Ni的浓度存在显著的相关关系,微量元素参与AR的发生和发展,为AR的诊断及治疗提供了重要依据。

Objective：To examine the relationship between trace elements and IL-4in patients with allergic rhinitis（AR）.Method：According to the inclusion and exclusion criteria,a total of 260 cases in AR group（130hui cases,130 han cases）,and 260 cases in normal control group（130hui cases,130 han cases）were recruited in this study.The concentrations of IL-4were detected by enzyme linked immunosorbent assay（ELISA）,the contents of Zn,Mn,Ni,Se and Fe were determined by inductively coupled plasma atomic emission spectrometry（ICP-AES）,and the correlation between the trace elements and IL-4were also analyzed.Result：IL-4levels in serum of both hui and han AR patients were higher than those in control group（P〈0.05）.Contents of serum Zn and Se in hui AR patients were lower than those in control group（P〈0.05）,Ni content was higher than that in control group（P〈0.05）;Zn level in serum of han AR cases was lower than that in control group,Ni content was higher than that in control group（P〈0.05）.The serum IL-4level in AR group was positively correlated with Ni（P〈0.01,r=0.671）,and negatively correlated with Zn（P〈0.01,r=-0.819）.Conclusion：We demonstrated that there are significant correlations between IL-4and Zn,Ni in the serum of patients with AR in Ningxia hui and han population.It indicates that trace elements are involved in the occurrence and development of AR,and may as a therauptic target of AR.