丹红注射液联合泮托拉唑钠治疗呼吸衰竭急性加重期患者的临床观察

Clinical Observation of Danhong Injection Combined with Pantoprazole in the Treatment of Acute Exacerbation of Respiratory Failure

目的:观察丹红注射液联合泮托拉唑治疗呼吸衰竭急性加重期患者的临床疗效及安全性。方法:选择呼吸衰竭急性加重期患者62例,按随机数字表法分为观察组和对照组,各31例。两组患者均给予吸氧、祛痰、气管插管、上呼吸机、纠正电解质平衡紊乱和酸碱平衡等常规治疗。对照组患者在常规治疗基础上给予丹红注射液4 ml+0.9%氯化钠注射液250 ml,ivgtt,qd;观察组患者在对照组基础上加用泮托拉唑钠注射液40 mg+0.9%氯化钠注射液100 ml,ivgtt,q12 h。两组患者均治疗15 d。观察两组患者的临床疗效及治疗前后的血气指标、血浆黏度及血浆乳酸水平,并记录不良反应情况。结果:观察组患者总有效率(90.32%)显著高于对照组(61.29%),差异有统计学意义(P<0.05)。治疗前,两组患者的动脉血氧分压(PaO_2)、血氧饱和度(SaO_2)、二氧化碳分压(PaCO_2)、血浆黏度、血浆乳酸水平比较,差异无统计学意义(P>0.05);治疗后,两组患者PaO_2、SaO_2、PaCO_2、血浆黏度、血浆乳酸水平均显著优于治疗前,且观察组显著优于对照组,差异有统计学意义(P<0.05)。两组患者均未见明显不良反应发生。结论:丹红注射液联合泮托拉唑钠治疗呼吸衰竭急性加重期患者疗效显著,能明显改善患者的血气指标、血浆黏度和血浆乳酸水平,且安全性较好。

OBJECTIVE： To observe the therapeutic efficacy and safety of Danhong injection combined with pantoprazole in the treatment of acute exacerbation of respiratory failure. METHODS： 62 patients with acute exacerbation of respiratory failure were selected and randomly divided into observation group and control group, with 31 cases in each group. Both group received Ox- ygen, expectorant, tracheal intubation and ventilation, and electrolyte balance and acid-base balance, routine treatment. Control group was given Danhong injection 40 ml added into 0.9% Sodium chloride solution 250 ml, ivgtt, qd; observation group was ad- ditionally given Pantoprazole injection 40 mg, q12 h. Both groups were treated for 15 d. Clinical efficacy of 2 groups were ob- served, and blood gas index, plasma viscosity and plasma lactate level were observed before and after treatment, and ADR was recorded. RESULTS： Total effective rate of observation group （90.32%） was significantly higher than that of control group （61.29%）, with statistical significance （P〈0.05）. Before treatment, there was no statistical significance in PaO2, SaO2, PaCO2, plasma viscosity and plasma lactate level between 2 groups （P〉0.05） ; after treatment, PaO2, SaO2, PaCO2, plasma viscosity and plasma lactate level of two group was significantly better than those of before treatment. The observation group was signoticanely beteer than the control group, with statistical significance （P〈0.05） ; no obvious ADR was found in 2 groups. CONCLUSIONS： Danhong injection combined with pantoprazole shows significant therapeutic efficacy and good safety in the treatment of acute exacerbation of respiratory failure.