天眩清注射液辅助治疗梅尼埃病的临床观察

Clinical Observation of Tianxuanqing Injection in Adjuvantive Treatment of Meniere's Disease

目的:观察中药制剂天眩清注射液辅助常规西医治疗梅尼埃病的临床疗效及安全性。方法:采用回顾性分析,选取102例确诊为梅尼埃病的患者,根据治疗方法不同分为研究组53例、对照组49例,两组患者均给予西医常规治疗(低分子右旋糖酐500 ml加三磷酸腺苷、辅酶A静脉滴注,qd,并口服地西泮),研究组患者在此基础上给予天眩清注射液600 mg加入5%葡萄糖注射液或0.9%氯化钠注射液中,ivgtt,qd,辅助治疗。7 d为1个疗程,两组患者均治疗2个疗程。结果:治疗后,两组患者的眩晕障碍量表(DHI)评分较治疗前降低,且研究组显著低于对照组,差异有统计学意义(P<0.05);治疗后研究组患者的眩晕症状治疗总有效率(83.02%)显著高于对照组(61.22%),差异有统计学意义(P<0.05);研究组患者的听力改善率(88.68%)亦显著高于对照组(73.47%),差异有统计学意义(P<0.05)。两组患者均未见明显不良反应。结论:中药制剂天眩清注射液辅助常规西医治疗梅尼埃病的临床疗效显著,且可显著改善患者的眩晕和听力症状,安全性好。

OBJECTIVE：To observe the clinical effect and safety of TCM preparation Tianxuanqing injection combined with conventional western medicine treatment for Meniere＇s disease. METHODS：102 patients diagnosed as Meniere＇s disease were selected retrospectively and divided into study group（53 cases）and control group（49 cases）according to treatment methods. Both groups received conventional western medicine treatment（dextran-40 500 ml added into ATP,coenzyme A for intravenous dripping,qd,oral administration of diazepam）,and study group was additionally given Tianxuanqing injection 600 mg added into 5%Glucose injection or normal saline ivgtt,qd for adjunctive therapy. A treatment course lasted for 7 d both groups received 2 courses of treatment. RESULTS：After treatment,DHI of 2 groups decreased compared to before treatment,study group was lower than that of control group,with statistical significance（P〈0.05）;total effective rate of study group（83.02%）was higher than that of control group（61.22%）,with statistical significance（P〈0.05）. The rate of hearing improvement in study group（88.68%）was higher than in control group（73.47%）,with statistical significance（P〈0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS：TCM preparation Tianxuanqing injection assisting conventional western medicine treatment shows significant clinical effect on Meniere＇s disease and can obviously improve vertigo and hearing symptom,with good safety.