血清降钙素原及C-反应蛋白对老年下呼吸道感染患者病情与预后评估中的作用

Effects of serum procalcitonin and C-reactive protein on assessment of illness condition and prognosis of elderly patients with lower respiratory tract infections

目的分析血清降钙素原(PCT)和C-反应蛋白(CRP)检测在老年人下呼吸道感染病情和预后评估中的作用,为合理治疗提供客观依据。方法选取2013年12月-2014年12月100例老年下呼吸道感染患者作为病例组,选取100名健康老年人作为对照组,对两组研究对象血清PCT和CRP水平进行检测和比较,对于病例组患者的呼吸衰竭发生率进行观察和记录;采用SPSS17.0软件进行统计分析。结果病例组患者的血清PCT和CRP水平均显著高于对照组,差异均有统计学意义(t=17.483、25.044,P<0.05);随着病情严重程度的加剧,患者的血清PCT和CRP水平呈现逐步上升,差异均有统计学意义(P<0.05);发生呼吸衰竭患者的血清PCT和CRP水平显著高于未发生呼吸衰竭,差异均有统计学意义(t=8.793、18.414,P<0.05)。结论老年下呼吸道感染患者表现为血清PCT和CRP水平均升高,其水平与患者的病情严重程度和预后具有相关性,可作为早期诊断、病情评估和预后预测的辅助指标。

OBJECTIVE To observe the effects of detection of serum procalcitonin（PCT）and C-reactive protein（CRP）on assessment of illness condition and prognosis of elderly patients with lower respiratory tract infections so as to provide guidance for reasonable clinical treatment.METHODS Totally 100 elderly patients with lower respiratory tract infections who were treated in the hospital from Dec 2013 to Dec 2014 were chosen as the case group,and 100 healthy elderly people were set as the control group.The levels of serum PCT and CRP were detected and compared between the two groups of study objects,the incidence of respiratory failure in the patients of the case group was observed and recorded,and the statistical analysis was performed with the use of SPSS17.0software.RESULTS The levels of serum PCT and CRP of the case group were significantly higher than those of the control group（t=17.483,25.044,P〈0.05）.With the exacerbation of severity of illness condition,the levels of serum PCT and CRP of the patients showed upward trends,and there was significant difference（P〈0.05）.The levels of serum PCT and CRP of the patients with respiratory failure were significantly higher than those of the patients without respiratory failure,and there was significant difference（t= 8.793,18.414,P〈0.05）.CONCLUSIONThe elderly patients with lower respiratory tract infections are characterized by the elevated levels of serum PCT and CRP,which are associated with the severity of illness condition and prognosis of the patients and can be used as subsidiary indexes for the early diagnosis,assessment of illness condition,and prediction of prognosis.