人巨细胞病毒感染在进展性动脉硬化性脑梗患者病情发展的作用研究

Effect of human cytomegalovirus infection on development of progressive atherosclerotic cerebral infarction

目的探讨人巨细胞病毒感染在进展性动脉硬化性脑梗死患者病情发展的作用,为临床诊断及治疗提供参考依据。方法选取医院2013年6月-2015年6月收治的72例动脉硬化性脑梗死患者为研究对象,作为观察组,另选同期82名健康体检者作为对照组,采用酶联免疫吸附试验(ELISA)方法检测两组巨细胞病毒(HCMV)IgM抗体,比较两组HCMV-IgM抗体的OD值及阳性率;采用PEMS3.1软件对数据进行处理。结果观察组患者OD值0.96±0.36高于对照组0.51±0.12,差异有统计学意义(t=19.587,P<0.05);观察组HCMVIgM抗体阳性率47.22%,高于对照组的13.41%,差异有统计学意义(χ2=18.541,P<0.05);全前循环梗死型的HCMV-IgM抗体阳性率100.00%,均高于部分前循环梗死阳性率47.62%、后循环梗死POCI阳性率的41.67%、腔隙性梗死阳性率的10.00%,HCMV-IgM抗体阳性率与分型呈负相关(P<0.05)。结论人巨细胞病毒感染是进展性动脉硬化性脑梗死病情发展的重要因素,通过检测巨细胞病毒IgM抗体,可为临床抗病毒药物治疗提供参考依据。

OBJECTIVE To explore the role of human cytomegalovirus infection in the development of progressive atherosclerosis cerebral infarction so as to provide guidance for clinical diagnosis and treatment.METHODS A total of 72 patients with atherosclerosis cerebral infarction who were treated in the hospital from Jun 2013 to Jun 2015 were recruited as the study objects and assigned as the observation group,meanwhile,82 healthy people who underwent the physical examination were chosen as the control group.The human cytomegalovirus（HCMV）IgM antibody was detected for the two groups by using enzyme-linked immunosorbent assay（ELISA）,the OD value and positive rates of HCMV-IgM were observed and compared between the two groups of patients,and the statistical analysis of data was performed with the use of PEMS3.1software.RESULTS The OD value of the observation group was（0.96±0.36）,higher than（0.51±0.12）of the control group,and there was significant difference（t=19.587,P〈0.05）.The positive rate of HCMV-IgM antibody of the observation group was 47.22%,higher than 13.41% of the control group,and there was significant difference（χ2=18.541,P〈0.05）.The positive rate of HCMV-IgM antibody of the patients with total anterior circulation infarction was 100.00%,higher than47.62% of the patients with partial anterior circulation infarction,41.67% of the patients with posterior circulation infarction,10.00% of the patients with lacunar infarction;the positive rate of HCMV-IgM antibody was negatively correlated with the type of atherosclerotic cerebral infarction（P〈0.05）.CONCLUSIONThe HCMV infection is an important factors for the development of progressive atherosclerosis cerebral infarction.The detection of the HCMV-IgM antibody can provide guidance for clinical antiviral therapy.