麦芪降糖丸联合胰岛素对妊娠期糖尿病患者相关指标的影响

Effects of Maiqi Jiangtang Pill Combined with Insulin on Related Indicators in Maternal Gestational Diabetes

目的：探讨麦芪降糖丸联合胰岛素对妊娠期糖尿病（GDM）患者相关指标的影响。方法：135例GDM患者随机分为对照组（69例）和观察组（66例）。对照组患者给予控制饮食,运动疗法,生物合成人胰岛素注射液,精蛋白生物合成人胰岛素注射液,按4∶2∶3∶1的比例以4-6单位分别于三餐前及睡前注射,并根据血糖监测结果决定是否需要调整胰岛素剂量（每次增减2-4单位）;观察组患者在对照组治疗的基础上给予麦芪降糖丸6 g,口服,每日4次。两组疗程均为15 d。观察两组患者分娩时的空腹血糖（FPG）、餐后2 h血糖（2 h PG）、糖化血红蛋白（Hb A1c）、体质量指数（BMI）,两组患者妊娠结局情况（子痫前期、早产、产褥感染、产后出血、新生儿窒息、低体质量儿、夜间低血糖）及不良反应发生情况。结果：观察组患者FPG、2 h PG、Hb A1c水平、BMI与子痫前期、早产、低体质量儿、新生儿窒息、夜间低血糖发生例数均显著低于对照组,差异均有统计学意义（P〈0.05）;但两组患者产褥感染、产后出血发生例数比较,差异均无统计学意义（P〉0.05）。两组妊娠期妇女治疗期间均未见明显不良反应发生。结论：麦芪降糖丸联合胰岛素可有效降低GDM患者的血糖,且安全性较好。

OBJECTIVE：To investigate the effects of Maiqi jiangtang pill combined with insulin on related indicators in maternal gestational diabetes. METHODS：135 GDM women were randomly divided into control group（69 cases） and observation group（66 cases）. Control group was given diet controlling and exercise therapy,Novolin R insulin biosynthesis and protamine synthetic human insulin were injected before meals and bedtime from 4-6 units with the ratio of 4 ∶ 2 ∶ 3 ∶ 1,and decided whether to adjust the insulin dose based on the blood glucose monitoring results（increase or decrease 2-4 units each times）;observation group was additionally given 6 g Maiqi jiangtang pill,4 times a day. The treatment course for both groups was 15 d. Fasting plasma glucose（FPG）,2 h postprandial glucose（2 h PG）,glycated hemoglobin（Hb A1c）,body mass index（BMI）,maternal pregnancy outcomes（preeclampsia,preterm labor,puerperal infection,postpartum hemorrhage,neonatal asphyxia,low-weight children and nocturnal hypoglycemia）and incidence of adverse reactions in 2 groups were observed. RESULTS：FPG,2 h PG,Hb A1 c,BMI,preeclampsia,preterm labor,low-weight children,neonatal asphyxia and nocturnal hypoglycemia in observation group were significantly lower than control group,the differences were statistically significant（P〈0.05）;there were no significant differences in the puerperal infection and postpartum hemorrhage between 2 groups（P〉0.05）. And there were obvious adverse reactions between 2groups during treatment. CONCLUSIONS：Maiqi jiangtang pill combined with insulin can effectively reduce the blood glucose of GDM women,with good safety.