摘要
目的:探讨麦芪降糖丸联合胰岛素对妊娠期糖尿病(GDM)患者相关指标的影响。方法:135例GDM患者随机分为对照组(69例)和观察组(66例)。对照组患者给予控制饮食,运动疗法,生物合成人胰岛素注射液,精蛋白生物合成人胰岛素注射液,按4∶2∶3∶1的比例以4-6单位分别于三餐前及睡前注射,并根据血糖监测结果决定是否需要调整胰岛素剂量(每次增减2-4单位);观察组患者在对照组治疗的基础上给予麦芪降糖丸6 g,口服,每日4次。两组疗程均为15 d。观察两组患者分娩时的空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(Hb A1c)、体质量指数(BMI),两组患者妊娠结局情况(子痫前期、早产、产褥感染、产后出血、新生儿窒息、低体质量儿、夜间低血糖)及不良反应发生情况。结果:观察组患者FPG、2 h PG、Hb A1c水平、BMI与子痫前期、早产、低体质量儿、新生儿窒息、夜间低血糖发生例数均显著低于对照组,差异均有统计学意义(P〈0.05);但两组患者产褥感染、产后出血发生例数比较,差异均无统计学意义(P〉0.05)。两组妊娠期妇女治疗期间均未见明显不良反应发生。结论:麦芪降糖丸联合胰岛素可有效降低GDM患者的血糖,且安全性较好。
OBJECTIVE:To investigate the effects of Maiqi jiangtang pill combined with insulin on related indicators in maternal gestational diabetes. METHODS:135 GDM women were randomly divided into control group(69 cases) and observation group(66 cases). Control group was given diet controlling and exercise therapy,Novolin R insulin biosynthesis and protamine synthetic human insulin were injected before meals and bedtime from 4-6 units with the ratio of 4 ∶ 2 ∶ 3 ∶ 1,and decided whether to adjust the insulin dose based on the blood glucose monitoring results(increase or decrease 2-4 units each times);observation group was additionally given 6 g Maiqi jiangtang pill,4 times a day. The treatment course for both groups was 15 d. Fasting plasma glucose(FPG),2 h postprandial glucose(2 h PG),glycated hemoglobin(Hb A1c),body mass index(BMI),maternal pregnancy outcomes(preeclampsia,preterm labor,puerperal infection,postpartum hemorrhage,neonatal asphyxia,low-weight children and nocturnal hypoglycemia)and incidence of adverse reactions in 2 groups were observed. RESULTS:FPG,2 h PG,Hb A1 c,BMI,preeclampsia,preterm labor,low-weight children,neonatal asphyxia and nocturnal hypoglycemia in observation group were significantly lower than control group,the differences were statistically significant(P〈0.05);there were no significant differences in the puerperal infection and postpartum hemorrhage between 2 groups(P〉0.05). And there were obvious adverse reactions between 2groups during treatment. CONCLUSIONS:Maiqi jiangtang pill combined with insulin can effectively reduce the blood glucose of GDM women,with good safety.
出处
《中国药房》
CAS
北大核心
2016年第15期2035-2037,共3页
China Pharmacy
基金
河北省科学技术研究与发展计划项目(No.12277764)
关键词
麦芪降糖丸
胰岛素
妊娠期糖尿病
血糖
妊娠结局
Maiqi jiangtang pill
Insulin
Gestational diabetes
Blood glucose
Maternal pregnancy outcomes