幽门螺杆菌感染与儿童过敏性紫癜及肾损害的相关性研究

Relationship between Helicobacter pylori infection and allergic purpura and renal damage of children

目的探讨幽门螺杆菌(Hp)感染与儿童过敏性紫癜(HSP)的相关性及其对患儿肾损害的影响,为临床治疗提供理论依据。方法选取2013年5月-2015年5月医院收治的HSP患儿64例作为病例组,另选取同期体检的64名健康儿童作为对照组;对两组儿童进行Hp检测,比较病例组中Hp感染与无Hp感染肾损害发生率,比较不同治疗方式的疗效及复发率;采用SPSS17.0软件进行统计分析。结果病例组患儿中检出Hp阳性42例,检出率为65.6%,对照组患儿中检出Hp阳性25例,检出率为39.1%,两组比较差异有统计学意义(P<0.05);Hp感染的HSP患儿中肾损害的发生率为64.3%,明显高于无Hp感染的HSP患儿,差异有统计学意义(P<0.05);抗Hp治疗组治疗总有效率为95.2%,较常规治疗组的71.4%明显提高,而HSP复发率明显降低,差异均有统计学意义(P<0.05)。结论 HSP患儿较正常儿童Hp感染率明显升高,Hp感染与儿童HSP发生具有密切相关性,Hp感染对HSP患儿肾损害具有明显影响,及时治疗Hp感染的HSP患儿能有效提高疗效,降低病情复发率,有助于患儿改善预后。

OBJECTIVE To explore the relationship between Helicobacter pylori infection and henoch-schonlein purpura（HSP）of children and observe the impact on renal damage of the children so as to provide theoretical basis for clinical treatment.METHODS Totally 64 children with HSP who were treated in hospitals from May 2013 to May 2015 were selected as the case group,meanwhile,64 healthy children who received the physical examination were set as the control group.H.pylori was detected for the two groups of children,the incidence of renal damage was compared between the children with H.pyloriinfection and the children without H.pyloriinfection in the case group.The effects and recurrence rates were observed and compared among the different treatment measures,and the statistical analysis was performed with the use of SPSS17.0software.RESULTS H.pylori was detected positive in 42 children in the case group,with the detection rate 65.6%;H.pylori was detected positive in 25 children in the control group,with the detection rate 39.1%,and there was significant difference between the two groups（P〈0.05）.Among the children with HSP,the incidence rate of renal damage was 64.3%in the children with H.pylori infection,significantly higher than that in the children without H.pylori infection（P〈0.05）.The total effective rate of treatment of the anti-H.pylori treatment group was 95.2%,significantly higher than71.4% of the conventional treatment group,however,the recurrence rate of HSP was significantly reduced（P〈0.05）.CONCLUSIONThe incidence of H.pylori infection is significantly higher in the children with HSP than in the healthy children and is closely associated with the incidence of HSP,and it has remarkable impact on renal damage of the children with HSP.The timely treatment of H.pylori infection can effectively improve the effect and reduce the recurrence rate,and it is conducive to the improvement of prognosis.