盐酸伊立替康在宫颈癌顺铂方案化疗治疗中的应用效果

Clinical Efficacy of Irinotecan Hydrochloride in Cisplatin Chemotherapy for Cervical Cancer

目的探讨盐酸伊立替康在宫颈癌顺铂方案化疗治疗中的应用效果。方法按照化疗方案不同将105例ⅠB~ⅡB期宫颈癌患者均分为实验组63例和对照组42例,实验组患者采取盐酸伊立替康联合顺铂方案化疗后行手术治疗,对照组患者仅采取顺铂方案化疗后行手术治疗,比较2组治疗效果。结果实验组患者RR率和手术实施率均明显高于对照组,差异具有统计学意义（P〈0.05）;2组患者化疗期间不良反应发生率比较,差异无统计学意义（P〉0.05）;实验组患者手术时间、术中出血量及并发症发生率均明显低于对照组,差异具有统计学意义（P〈0.05）;实验组患者宫颈深肌层浸润、宫旁浸润、盆腔淋巴结转移、阴道切缘阳性和脉管癌栓发生率均明显低于对照组,差异具有统计学意义（P〈0.05）。结论盐酸伊立替康能够有效提高顺铂化疗效果,为手术治疗创造有利条件,提高手术质量,降低术后并发症及术后病理高危因素发生率,可作为优选治疗方案。

Objective To explore the clinical efficacy of irinotecan hydrochloride in cisplatin chemotherapy for cervical cancer. Methods 105 cases of patients with ⅠB - ⅡB cervical cancer were divided into the experiment group（ 63 cases） and the control group（ 42 cases） according to different treatment methods. The experiment group were treated by irinotecan hydrochloride combined with cisplatin,the control group were treated by cisplatin. The clinical effects were compared between the 2 groups.Results The rates of RR and operation implementation of the experiment group were higher than those of the control group（ P〈0. 05）; There had no significant difference in the rate of toxic reactions（ P〉0. 05）; The time of operation,intraoperative blood loss,complication of the experiment group were lower than those the control group（ P〈0. 05）; The rate of deep cervical muscle layer infiltration,parametrial infiltration,pelvic lymph node metastasis,vaginal cut edge positive,vessel carcinoma embolus of the experiment group were lower than those of the control group（ P〈0. 05）. Conclusion Irinotecan hydrochloride can improve the clinical effects of cisplatin,create favorable conditions for surgical treatment,improve the quality of surgery,reduce the postoperative complications and postoperative pathological risk factors. It can be used as optimal treatment plan.