丁苯酞联合神经节苷酯对老年缺血性脑血管病患者血小板聚集水平及神经功能学评分的影响

Influence of Butylphthalide Joint Ganglioside on Platelet Aggregation Level and Nerve Dysfunction Score of Elderly Patients with Ischemic Cerebrovascular Disease

目的分析并探讨丁苯酞联合神经节苷脂对老年缺血性脑血管病患者血小板聚集水平(PAL)及神经功能学评分(NDS)的影响。方法选取2014年3月至2015年3月在长江大学附属第一医院接受治疗的老年缺血性脑血管病患者50例,采用随机数字表分为观察组和对照组,各25例。两组患者均给予常规的支持治疗,包括血糖和血压的控制,常规口服阿司匹林肠溶片,100 mg/次,1次/d。在此基础上,观察组给予丁苯酞联合神经节苷脂治疗,对照组仅给予丁苯酞治疗,丁苯酞口服,0.2 g/次,3次/d。神经节苷脂100 mg加入到250 m L 0.9%Na Cl溶液中,静脉注射,1次/d。连续治疗10 d。观察两组患者治疗后临床效果及血小板聚集水平(PAL)和NDS评分。结果观察组有效率显著高于对照组[84.0%(21/25)比56.0%(14/25)],差异有统计学意义(P<0.05)。治疗后,观察组总胆固醇、三酰甘油以及低密度脂蛋白水平与对照组比较,差异无统计学意义[(5.0±1.0)mmol/L比(5.5±1.1)mmol/L,(1.5±0.3)mmol/L比(1.7±0.4)mmol/L,(2.9±0.5)mmol/L比(3.1±0.6)mmol/L,P>0.05]。观察组PAL、NDS评分显著低于对照组[(52.7±3.2)%比(59.4±3.0)%,(5.2±2.1)分比(7.5±2.5)分],差异有统计学意义(P<0.05)。结论丁苯酞联合神经节苷脂对老年缺血性脑血管病患者临床效果显著,可有效地改善PAL和NDS评分,临床上值得推广。

Objective To analyze and discuss the effect of butylphthalide joint ganglioside on platelet aggregation level（PAL） and nerve dysfunction scores（NDS） of patients with elderly patients with ischemlc cerebrovascular disease. Methods Total of 50 elderly patients with isehemic cerebrovascular disease in the First Affiliated Hospital of the Yangtze University from Mar. 2014 to Mar. 2015 were included in the study, and divided into observation group and control group according to random number table metod, 25 cases each. Both groups were given routine supportive care, including blood glucose and blood pressure control, reg- ular aspirin enteric-coated tablets, 100 mg/time, 1 time/d. On this basis, the observation group was given butylphthalide joint ganglioside treatment, while the control group only received butylphthalide treatment, oral,0. 2 g/time,3 times/d,ganglioside 100 mg added into 250 mL of O. 9% NaC1 solution for intravenous injection, 1 time/d. Both groups were treated for 10 d continuously. The clinical effects, PAL and NDS score of the two groups after treatment were observed. Results The effective rate of the observation group was sig- nificantly higher than the control group [ 84. 0% （21/25） vs 56. 0% （ 14/25 ） ] ,the difference was statisti- cally significant（ P 〈 0. 05 ）. After treatment, the total cholesterol, trigiyceride and LDL level in the observa- tion group and the control group were not statistically significantly different[ （5.0±1. 0） mmol/L vs （5.4 ± 1.1） retool/L,（1.5＋0.3） mmol/L vs （1.7 ±0.4） retool/L,（2.9 ±0.5） mmol/Lvs （3.1 ±0.6）mmol/L,P 〉0. 05 ]. PAL,NDS score in the observation group was significantly lower than the control group [ （52. 7 ± 3.2） % vs （59.4 ~ 3.0） %, （ 5.2 ± 2. 1 ） scores vs （ 7.5 ± 2. 5 ） scores ] , the differences were statistically significant（ P 〈 0. 05）. Conclusion Clinical effect of butyphthalide joint ganglioside in elderly patients with ischemic cerebrovascular disease is significant, which can effectively improve the PAL and NDS score, thus is worthy of clinical promotion.