保妇康栓联合康复新液外用对真菌性阴道炎患者微生物环境的影响

Effect of Baofukang Suppository Combined with Kangfuxin Liquid on Microbial Environment of Patients with Fungal Vaginitis

目的探讨保妇康栓联合康复新液外用对真菌性阴道炎患者微生物环境的影响。方法选取2014年3月至2015年3月十堰市太和医院(湖北医药学院附属医院)收治的74例真菌性阴道炎患者为研究对象,按照随机数字表法分为对照组和观察组,每组37例。对照组采用保妇康栓治疗,将其放置在阴道中,每晚1粒(1.74 g);观察组采取保妇康栓联合康复新治疗,80 m L康复新液加入水中,进行10 min的局部清洗,每日3次,冲洗完毕后将1粒保妇康栓放置在阴道中,两组患者的疗程均为2周。比较两组患者的T细胞亚群各项指标,临床症状缓解时间,临床疗效,分泌物阴性率与复发情况及不良反应发生率。结果治疗后,观察组患者的CD4、CD4/CD8指标低于对照组[(41.14±6.57)%比(45.05±7.47)%、1.35±0.15比1.52±0.22],CD8高于对照组[(26.47±6.28)%比(20.11±5.01)%],差异有统计学意义(P<0.05)。观察组患者阴道充血糜烂消失、阴道分泌物减少及阴道与外阴瘙痒灼热消失时间短于对照组[(4.1±0.4)d比(8.2±0.8)d、(6.2±0.7)d比(9.2±1.1)d、(5.1±0.5)d比(9.0±1.1)d],差异有统计学意义(P<0.01)。观察组患者总有效率高于对照组[91.9%(34/37)比73.0%(27/37)],差异有统计学意义(P<0.05)。治疗后1个月,观察组患者的分泌物阴性率高于对照组[89.2%(33/37)比62.2%(23/37)],复发率低于对照组[5.7%(2/35)比30.3%(10/33)],差异有统计学意义(P<0.05)。结论保妇康栓联合康复新液外用有利于真菌性阴道炎患者微生物环境的改善,增强患者的免疫功能,复发率较低,临床疗效良好,安全性高。

Objective To study the effect of baofukang suppository combined with kangfuxin Liquid on the microbial environment of patients with fungal vaginifis. Methods Total of 74 patients with fungal vagini- tis in Shiyan Taihe Hospital Affiliated Hospital of Hubei University of Medicine from Mar. 2014 to Mar. 2015 were included in the study, according to the random number table method they were divided into observation group and control group ,37 cases in each group. The control group was given baofukang suppository, placed in vagina, 1 piece（ 1.74 g） every night;the observation group adopted baofukang suppository combined with kangfuxin treatment,80 mL kangfuxin solution was added water for 10 min of local cleaning,3 times a day, after the completion of the wash, a Baofukang vaginal suppository was placed in the vagina. The course of treatment of both groups was 2 weeks. They were compared with the T cell subsets, the clinical symptoms improving time, the clinical efficacy, the negative rate of secretion, the recurrence rate, and the adverse reac- tion rate. Results After treatment, CD4 , CD4/CDs of the observation group were lower than the control group[ （41.14 ± 6. 57 ）% vs （45.05 ±7.47 ）%, 1.35 ± 0. 15 vs 1.52 ± 0. 22 ], CDs higher than the con- trol group[ （26. 47 ± 6.28 ） % vs （ 20. 11 ± 5.01 ） % ], the differences were statistically significant （ P 〈 0. 05 ）. The vaginal congestion erosion disappearance, vaginal secretions reduction and vaginal vulva itching burning disappearing time of the observation group were significantly shorter than the control group[ （4. 1 ± 0.4） dvs （8.2±0.8） d,（6.2±0.7） d vs （9.2±1.1） d,（5.1 ±0.5） dvs （9.0±1.1） d]（P〈 0. 01 ）. Clinical efficacy of the observation group 91.9% （34/37） was significantly higher than the control group 73.0% （27/37）, the difference was statistically significant （P 〈 0.05 ）. One month after treatment, the negative rate of vaginal secretion of the observation group 89. 2% （33/37） was significantly higher than the control group 62. 2% （23/37） ,the recurrence rate 5.7% （2/35） was significantly lower than the control group 30. 3% （ 10/33 ） ,the differences were statistically significant（P 〈0. 05）. Conclusion Baofukang sup- pository combined with kangfuxin liquid is conducive to improve microbial environment of patients with fungal vaginitis and enhance the immune function,with low recurrence rate,good clinical effect and safety.