系统性红斑狼疮相关性塌陷性肾小球病研究进展

Systemic lupus erythematosus-associated collapsing glomerulopathy

塌陷性肾小球病(collapsing glomerulopathy,CG)最初是在人类免疫缺陷病毒(human immunodeficiency virus,HIV)阳性患者中发现的一种特别的肾脏病,现在认为它与许多其他的疾病相关,比如系统性红斑狼疮(systemic lupus erythematosus,SLE)。SLE相关性CG(SLE-associated CG)是指在SLE患者中发现的一种罕见的临床病理实体,并除外其他引起CG的主要因素(比如HIV、细胞病毒B19、丙肝病毒、药物等),临床上以大量蛋白尿,对免疫抑制剂治疗反应差和急进性肾功能恶化为特点。本文对近年来国外有关SLE相关性CG的研究进展进行综述。

Collapsing glomerulopathy（CG）, once known as a special renal disease in human immunodeficiency virus （HIV）-positive patients, has since been recognized in association with numerous other conditions, such as systemic lupus erythematosus （SLE）. SLE- associated CG is a distinct clinicopathologic entity in patients with SLE who are not associated with HIV,parvovirus B19,hepatitis C virus, drugs or the primary causes of CG, and is characterized by significant proteinuria, poor response to immunosuppressive therapy, and rapid progression to renal failure. In this article,we review recent progress on SLE-associated CG.