吡嗪酰胺治疗耐多药肺结核的临床效果观察

Observation on clinical effects of pyrazinamide on multidrug-resistant tuberculosis

目的探讨吡嗪酰胺治疗耐多药肺结核的临床效果。方法 2014年1月~2015年8月选择在我院诊治的耐多药肺结核病患者84例,随机分为治疗组与对照组各42例,治疗组给予基于吡嗪酰胺的抗痨方案治疗,对照组除了不给予吡嗪酰胺外,其他治疗方案同治疗组,观察两组的显效率和痰菌阴转率,同时记录两组治疗期间的不良反应情况。结果治疗后与对照组相比,治疗组的显效率和痰菌阴转率明显较高（P〈0.05）。治疗期间,两组的胃肠道反应、皮疹、肝功能异常、白细胞减少等不良反应发生情况无统计学差异（P〉0.05）。结论耐多药肺结核病治疗方案中使用吡嗪酰胺能提高痰菌阴转率,改善综合治疗效果,安全性也比较好,有很好的应用价值。

Objective To investigate the clinical effects of pyrazinamide on multidrug-resistant tuberculosis. Methods 84 patients with multidrug-resistant tuberculosis treated between January 2014 and August 2015 were selected and averagely and randomly divided into treatment and control groups. The treatment group was given the pyrazinamide based chemotherapy, and the control group was given the same treatment as the treatment group except pyrazinamide. The efficiency and sputum negative conversion rate of the two groups were observed, and at the same time the adverse events during treatment in both groups were recorded. Results After the treatment, the efficiency and sputum negative conversion rate in the treatment group were higher than those in the control group（P 0.05）. During the treatment, there were no significant differences in the adverse reactions like gastrointestinal reaction, rash, abnormal liver function, and leucopenia renal dysfunction, etc. between the two groups. Conclusion The use of pyrazinamide in the treatment of multidrug-resistant tuberculosis can improve the sputum negative conversion rate and the overall treatment effects, which has better safety and more application value.