半夏泻心汤加味辅助吸入抗胆碱气雾剂治疗胃食管反流相关性支气管哮喘

Efficacy of Modified Banxia Xiexin Decoction Assisted with Anti-choline Aerosol for Gastroesophageal Reflux Combined with Bronchial Asthma

目的:观察自拟半夏泻心汤加味辅助吸入抗胆碱气雾剂治疗胃食管反流相关性支气管哮喘的疗效。方法:选取2013年5月—2015年5月三亚市中医院收治的经确诊为胃食管反流相关性支气管哮喘患者82例,随机分为观察组和对照组,各41例。对照组患者给予抗胆碱气雾剂常规对症治疗,观察组患者在对照组患者治疗的基础上接受自拟半夏泻心汤加味治疗。比较治疗前后两组患者胃食管反流症状评分、支气管哮喘控制评分、肺功能、以及中医证候疗效。结果:治疗后,观察组患者胃食管反流症状评分与治疗前比较显著下降(P<0.01);观察组患者胃食管反流症状评分显著低于同期对照组(P<0.01);两组患者支气管哮喘控制评分均较治疗前改善(P<0.01),观察组患者较同期对照组改善更加显著(P<0.01);两组患者的第1秒用力呼气容积占预计值百分比(FEV1%)和最大呼气流速占预计值百分比(PEV%)均较治疗前显著上升(P<0.01),观察组患者较同期对照组上升更加显著(P<0.01)。治疗8周后,观察组中医证候疗效明显优于对照组(P<0.05)。结论:半夏泻心汤加味辅助吸入抗胆碱气雾剂治疗胃食管反流相关性支气管哮喘患者的临床疗效显著,能有效改善患者胃食管反流症状,有效控制哮喘,改善患者肺功能。

Objective： To observe the efficacy of modified Banxia Xiexin decoction assisted with anticholine aerosol for gastroesophageal reflux combined with bronchial asthma. Method： The 82 patients with gastroesophageal reflux combined with bronchial asthma in our hospital from May 2013 to May 2015 were selected as research objects and randomly divided into observation group and control group,41 cases in each group.Patients in control group were treated with conventional anti-choline aerosol therapy,while patients in observation group received modified Banxia Xiexin decoction on the basis of the treatment of the control group. The symptom scores of gastroesophageal reflux and bronchial asthma control,lung functions,and efficacy of traditional Chinese medicine syndrome were observed and compared before and after treatment in two groups. Result： The symptom scores of gastroesophageal reflux in the observation group after treatment were significantly lower than those before treatment（ P〈0. 01）. The symptom scores of gastroesophageal reflux in observation group were significantly lower than those in the control group at the same period（ P〈0. 01）. The scores of bronchial asthma control were improved after treatment in both groups（ P〈0. 01）,and the improvement in observation group was more obvious than that in control group（ P〈0. 01）. The first second forced expiratory volume（ FEV1%） and maximum expiratory flow rate（ PEV%） were significantly increased after treatment in both groups（ P〈0. 01）,and the increase was more obvious in the observation group than that in the control group（ P〈0. 01）. After treatment for 8weeks,the efficacy of traditional Chinese medicine syndrome in the observation group was significantly better than that of the control group（ P〈0. 05）. Conclusion： The clinical efficacy of modified Banxia Xiexin decoction assisted with anti-choline aerosol for gastroesophageal reflux combined with bronchial asthma was remarkable,and could effectively improve gastroesophageal reflux symptoms,control bronchial asthma and improve lung functions of the patients.