宣肺解毒颗粒治疗发作期变应性鼻炎(肺经郁热型)的临床疗效

Clinical Effect of Xuanfei Jiedu Granules Inhalation on Allergic Rhinitis(Lung Heat Type)

目的:评价宣肺解毒颗粒治疗肺经郁热型变应性鼻炎(AR)的临床疗效和与安全性。方法:222例AR患者随机按数字表法分为对照组(102例)和观察组(120例)。对照组采用布地奈德气雾剂,200~1 600μg·d^(-1),分成2~4次使用;观察组采用宣肺解毒颗粒内服,10 g/次,2次/d。两组疗程均为7 d。采用视觉模拟量表(VAS)对治疗前后鼻塞、鼻痒、喷嚏、流涕4个症状进行评价,计录4个主要症状减轻时间(记分≤3分)和消失时间(记分为0分);采用鼻结膜炎生命质量调查问卷(RQLQ)评价患者生活质量;记录治疗期间不良反应。结果:两组治疗后鼻塞、鼻痒、喷嚏、流涕VAS评分均较治疗前明显下降(P<0.01);治疗后观察组鼻痒和喷嚏评分均低于对照组(P<0.01),治疗后两组鼻塞和流涕评分组间比较差异均无统计学意义;两组鼻塞、鼻痒、喷嚏、流涕减轻时间比较差异均无统计学意义;观察组鼻塞、鼻痒、喷嚏消失时间短于对照组(P<0.05,P<0.01),流涕消失时间比较差异无统计学意义;两组治疗后RQLQ量表活动、睡眠、非鼻炎症状、相关行为、鼻部症状、眼部症状、情感等7个维度评分和总分均较治疗前下降(P<0.01),观察组活动、鼻部症状、眼部症状及RQLQ量表总分均低于对照组(P<0.05,P<0.01);两组治疗期间均无严重不良反应发生。结论:与布地奈德气雾剂相比较,宣肺解毒颗用于肺经郁热型AR,在控制症状发作、提高患者生活质量方面均显示出了一定的优势;且安全性较高,值得临床使用和进一步的研究。

Objective： To discuss clinical effect and safety of Xuanfei Jiedu granules in treating allergic rhinitis（ AR,lung heat type）. Method： Two hundred and twenty-two patients with AR were randomly divided into control group（ 102 cases） and observation group（ 120 cases） by random number table. Patients in control group orally took budesonide aerosol inhalation for 2-4 times,200-1 600 μg/day. Patients in observation group took Xuanfei Jiedu granules,10 g/time,2 times/day. Courses of treatment lasted for 7 days. Before and after treatment,scores of nasal obstruction, rhinocnesmus, sternutation and rhinorrhoea were evaluated by visual analogue scale（ VAS）,and time of relief for the main symptoms（ score≤3） and elapsed time（ score = 0） were recorded. Patients＇ qualities of live were evaluated by rhinoconjunctivitis quality of life questionnaire（ RQLQ）.And adverse reactions were recorded. Result： VAS scores, such as nasal obstruction, rhinocnesmus,sternutation and rhinorrhoea,obviously decreased after treatment（ P〈0. 01）,and scores of rhinocnesmus and sternutation decreased in observation group were lower than those in control group（ P〈0. 01）,with no statistically significant difference in scores of nasal obstruction and rhinorrhoea and time of relief of the four symptoms between the two groups. Elapsed time of nasal obstruction,rhinocnesmus and sternutation in observation group were shorter than those in control group（ P〈0. 05,P〈0. 01）,with no statistical significant difference in elapsed time of rhinorrhoea. After treatment,scores of motion,sleep,no-rhinitis symptoms,relevant behaviors,sniffle,ocular symptoms,emotion and total scores in both groups decreased（ P〈0. 01）. And scores of motion,sniffle,ocular symptoms and total scores in observation group were lower than those in control group（ P〈0. 05,P〈0. 01）.During the treatment, there was no serious adverse reaction in both groups. Conclusion： Compared with budesonide aerosol inhalation,Xuanfei Jiedu granules is better in controlling onset of symptom,improving patients＇ qualities of live and safer in the treatment of AR（ lung heat type）,and so worth further studies.