2-羟基-6-三氟甲基吡啶的合成

Synthesis of 2-hydroxy-6-trifluoromethyl pyridine

以乙烯基乙醚为起始原料,经与三氟乙酸酐进行醚化反应,再与氰基乙酰胺进行成环反应,随后在20%的氢氧化钠水溶液中水解,最后在喹啉中高温脱羧共四步反应合成得到2-羟基-6-三氟甲基吡啶,并进行了核磁共振谱的结构表征,该法具有原料成本较低,后处理简单,易操作,收率高的特点。

2-hydroxy-6-trifluoromethyl pyridine was synthesized by four steps in total to yield the product , with the vinyl ether as starting materials , via an etherification reaction with trifluoro acetic anhydride , after the cyclization reaction with cyanoacetamide, then, hydrolysis reaction with 20%NaOH aqueous solution, the last, a decarboxylation reaction with quinoline in the high temperature .The target and intermediates were all characterized by 1 H NMR.This method has the characteristics of low cost , simple operation , easily separated and high yield .