子宫次全切除术后残留宫颈人乳头瘤病毒易感性研究

Study on the Susceptibility of Residual Cervical HPV after Subtotal Hysterectomy

目的通过观察子宫次全切除术后残留宫颈细胞学异常和人乳头瘤病毒(HPV)的易感性和清除率,为子宫次全切除式的选择、保留宫颈治疗方案提供理论依据。方法行子宫次全切除术的45例患者,依据HPV感染情况分为阴性和阳性两组,同时期健康体检者为对照组,分别于术后第1月、3月、6月行新柏氏液基细胞学检测(TCT),术后6月检测残留宫颈基质金属蛋白9(MMP-9)的表达情况及HPV感染率。结果术后1、3、6月TCT检测未见异形细胞;术后6月患者残留宫颈MMP-9与健康者比较,差异无统计学意义(P>0.05);术前HPV阴性组、阳性组HPV感染率及HPV L1阳性率分别与对照组比较,差异无统计学意义(P>0.05)。结论子宫次全切除术后半年内不会引起残留宫颈细胞学异常和HPV感染的爆发,与健康人群发生率一致,不增加宫颈发生病变的风险。

Objective To provide a theoretical basis for the uterus selection, cervical treatment programs through the observation of subtotal hysterectomy postoperative residual abnormal cervical cytology and human papilloma virus （human papilloma virus （HPV） susceptibility and clearance rate.Methods For uterus resection of 45 cases of patients, according to HPV infection were divided into negative and positive group, also healthy subjects as control group respective- ly, then in operation after 1 month, 3 months, 6 months, residual cervical stroma metal egg white 9 （MMP-9） expression and HPV infection rate were detected 6 months after operation withThinPrep liquid based cytology test （TCT）.Results 1 month, 3 months, and 6 months after operation TCT detected no abnormal cells; after 6 months in patients with residual cervical M MP-9 and healthy people, the difference was not statistically significant （P〉0.05） ;preoperative HPV negative group and positive group,the HPV infection rate and the infection of HPV L1 positive rate respectively with the control group, the difference was not statistically significant （P〈0.05）.Conclusion Within six months hysterectomy will not cause residual cervical cytology abnormalities and HPV infection outbreak, or will not increase the risk of cervical lesions.