食管癌术后继发纵隔淋巴结转移同步放化疗疗效观察

Clinical effects investigation of synchronous radiotherapy and chemotherapy on secondary mediastinal lymph node metastasis after esophageal carcinoma resection

目的：探讨食管癌术后继发纵隔淋巴结转移的患者单纯放疗与同步放化疗的临床疗效及安全性差异。方法：研究对象选取2011年8月-2013年1月收治食管癌术后继发纵隔淋巴结转移的患者共130例，随机分为对照组（65例）和治疗组（65例），分别给予单纯放疗和同步放化疗方案治疗；比较两组患者临床疗效，随访生存率及不良反应发生率等。结果：治疗组患者临床疗效显著优于对照组，差异有显著性意义（P〈0．05）；治疗组患者随访生存率显著高于对照组，差异有显著性意义（P〈0．05）；两组患者不良反应发生率比较差异无显著性意义（P〉0．05）。结论：相较于单纯放疗，同步放化疗方案治疗食管癌术后继发纵隔淋巴结转移的患者可有效延缓病情进展，提高远期生存率，且未增加不良反应发生风险。

Objective：To investigate the clinincal effect and safety differences of radiotherapy used alone and synehronous radiotherapy and chemotherapy on secondary mediastinal lymph node metastasis after esophageal carionoma resection,Methods：130 patients with econdary mediastinal lymph node metastasis after esophageal carinoma resection were chosen in the period from August 2011 to January 2013 in our hospital and randomly divided into two groups including control group（65 pationts）with radiotherapy used alone and treatment group（65 patients）with synchronous radiotherapy and chemotherapy;and the clinical effects ,the survival rate and the adverse reactions ineidence of both groups were compared.Results：The clinical effectos of treatment group was significant better than clntrol group（P〈0.05）.The survival rate of treatment group was significant better than control group （P〈0.05）,There was no significant difference in the adverse reactions incidence between 2 groups（P〉0.05）.Conclusion：Compared with radiotherapy used alone,synchronous radiotherapy and chemotherapy on secondary mediastinal lymph node metastasis arfter esophageal carinoma resection can effeiently delay the disease progress,improve the long-term survival rate and did not increase the risk of adverse reactions.