重度高胆红素血症新生儿总胆红素/白蛋白比值与MRI成像异常的相关性探讨

Study on correlation between B/A Ratio and abnormal brain MRI in neonates with severe hyperbilirubinemia

目的探讨重度高胆红素血症的新生儿总胆红素/白蛋白的比值(B/A)与颅脑核磁(MRI)异常的关系及其临床意义。方法对象为2013年1月-2014年1月收治的足月重度高胆红素血症(血清总胆红素≥342.2μmol/L)162例,按照颅脑核磁结果,分为核磁检查正常组(126例)及核磁检查异常组(36例)。回顾性分析B/A比值与颅脑核磁的关系。结果分析结果显示:颅脑核磁异常组较颅脑核磁正常组具有更高的B/A比值,差异具有统计学意义(P<0.05)。结论高B/A比值是重度高胆红素血症患儿发生颅脑核磁异常的危险因素,可能导致患儿遗留神经行为后遗症,对于无条件行磁共振检查的基层医院通过观察B/A值,对高B/A重度高胆红素血症新生儿积极退黄疸尽可能减少其遗留神经系统后遗症的机率,并加强高危患儿的随访工作。

Objective To investigate the relationship with neonatal hyperbilirubinemia between total bilirubin / albumin ratio（B/A）with brain magnetic resonance imaging （MRI） abnormalities and its clinical significance. Methods A total of 162 neonates hyperbilirubinemia （total serum bilirubin 9342.2 μmol / L） between January 2013 and January 2014 enrolled in the study. They were divided into two groups,according to the results of brain MRI： normal MRI group （n= 126） and abnormal MRI group （n= 36）. Retrospective analysis of the relationship between B/A ratio of brain magnetic resonance imaging. Result The results showed that the abnormal MRI group had a higher B/A ratio compared with the normal MRI group, it reached statistical significance （P〈0.05）. Conclusions High B/A ratio is a risk factor for abnormal MRI neonates with severe hyperbilirubinemia, which is the reason that could cause neurobehavioral sequelae of neonates. Primary hospital through observe B/A, high B/A ratiowith severe hyperbilirubinemia shoud active cut down jaundice, reduce neurobehavioraI sequelae of neonates,enhance follow-up of high rise children.