胆汁酸在胆道闭锁疾病中的研究进展

Research progress of bile acid in biliary atresia

胆道闭锁（biliary atresia）是以进行性肝内外胆管纤维化为特征的疾病，是导致婴幼儿终末期肝病的重要原因，目前病因及发病机制尚不明确。研究表明，胆汁酸可以用于胆道闭锁早期筛查、预后评估及胆管炎诊断。本文对近些年胆汁酸在胆道闭锁中的相关研究进展进行综述。

Characterized by progressive fibroinflammatory obstruction of intra- or extra-hepatic bile ducts, pediatric biliary atresia （BA） is frequently managed by liver transplantation. Its etiology and pathogenesis has remained illusive. Bile acid is presumed to be an excellent indicator for early screening, prognostic evaluation and cholangitis diagnosis. This review offers a latest summary of research progress of bile acid in BA.