摘要
大脑发育调节脑蛋白（Drebrin）是主要分布在神经元树突棘的肌动蛋白结合蛋白，其在树突棘的形成、突触形态的调节、记忆的保持等过程中起到重要作用。在一些中枢神经系统疾病如阿尔茨海默病的脑组织中，Drebrin的含量和分布发生了变化。已有研究者对其中的相关性进行了大量研究，但具体的机制目前仍不明确。更深入地研究此类中枢神经系统疾病和Drebrin的机制以及Drebrin与相关分子之间的关系，对于探索更为有效的治疗靶点具有重要意义。
Developmentally regulated brain protein （Drebrin）, which is a kind of actin binding protein, mainly distributes in the neuronal dendritic spines. It plays an important role in the processes of formation of dendritic spines, adjustment of synaptic morphology, and memory keep. The quantity and distribution of Drebrin changed in some of the central nervous system diseases such as Alzheimer＇s disease in brain tissues. Researchers have made much effort to find the correlation of them, but the exact mechanism is unclear. A more in-depth study on mechanism of Drebrin in the central nervous system disease and correlation of Drebrin with associated molecule has great significance to exploration of more effective therapeutic targets.
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2016年第5期514-518,共5页
Chinese Journal of Neuromedicine
基金
国家高技术研究发展计划（863计划）课题实施方案（SS2012AA022613）
