叶酸干预对复发性流产患者同型半胱氨酸及叶酸水平的影响探讨

Effect of folic acid intervention on homocysteine and folic acid levels for patients with recurrent spontaneous abortion

目的探讨叶酸干预对复发性流产患者同型半胱氨酸(HCY)及叶酸水平的影响。方法以42例复发性流产患者为研究对象,45例正常孕前检查者为对照,检测2组血清HCY水平、叶酸水平,根据检查结果给予叶酸干预,比较干预后2组HCY、叶酸水平。结果入组时复发性流产组血清HCY、血浆叶酸及红细胞叶酸水平与对照组比较差异均有统计学意义(P<0.05)。用药3个月后,复发性流产组血清HCY水平仍然显著高于对照组(P<0.05),红细胞叶酸水平显著低于对照组(P<0.05),但是血浆叶酸水平接近对照组,差异无统计学意义(P>0.05)。结论复发性流产患者血清同型半胱氨酸水平高于正常女性,叶酸水平偏低,叶酸干预可改善患者叶酸代谢紊乱、降低同型半胱氨酸水平。

Objective To investigate the effect offolic acid intervention on homocysteine （HCY） and folate levels for patients with recurrent spontaneous abortion （RPA）. Methods Made 42 cases of patients with recurrent spontaneous abortion as the research object and 45 cases of normal pregnancy examination women as control, serum Hcy level, folate levels of two groups were detected, according to the results of the examination give folic acid, Hey, folate levels after intervention were compared. Results The level of serum HCY, plasma folate and red cell folate ievels in RPA group at baseline were significant differences from control group （P〈0.05）. After 3 months, the serum HCY level in RAB group was significantly higher than that in control group （P〈0.05）, and the level of red cell folate was significantly lower than that in control group （P〈0.05）, however, plasma folate level was close to the control group （P〉0.05）. Conclusion Serum HCY level in patients with recurrent spontaneous abortion is higher than that of normal women, and the level of folic acid is low, the intervention of folie acid can improve the metabolic disorders and reduce the level of HCY.