头孢三嗪在结直肠手术中预防应用的研究

The study of prophylaxis administration ofceftriaxone in colorectal surgery Gao Fusheng,Liu Yuchun,Zhang Pu

目的:探讨头孢三嗪预防结直肠手术后感染的药代动力学依据。方法:选12例结直肠癌患者,在麻醉诱导期单剂量静脉滴注头孢三嗪2g,给药后在0.5h和3h分别取动脉血、腹部脂肪和腹直肌适量,并取结肠和肿瘤组织标本。用微生物法测定药物浓度。结果:动脉血的浓度分别为230.67±36.69μg/ml和132.72±18.84μg/ml;腹壁脂肪分别为13.80±3.58ug/g和7.87±4.77ug/g;腹直肌分别为10.68±5.01ug/g和7.14±3.86ug/g,结肠和肿瘤分别为29.09±6.78ug/g和22.63±11.08ug/g。结论:麻醉诱导期单剂量静脉滴注头孢三嗪2g,在手术期间可提供有效的血液和组织药物浓度。

Objective: To search for a pharmacokinetic gist of ceftriaxone(CTRX)in the prevention of infections after colorectal surgery. Methods: 12 cases of colorectal cancer patients were injected single - dose CTRX 2 g intravenously during the induction of anaesthesia. Microbiological method was used to moniter the CTRX concentrations in the arterial bloods , abdominal fat tissues, abdominal muscles, colorectal tissues and tumour tissues at 0. 5 and 3 hours after ceftriaxone administration. Results : Arterial blood CTRX concentrations are:230. 67±36. 69μg/ml and 132. 72±18. 84μg/ml separately;abdominal fat tissues are:13. 80±3. 58ug/g and 7. 87±4. 77ug/g;abdominal muscles are:10. 68±5. 01ug/g and 7. 14±3. 86ug/g;colorectal and tumour tissues are:29. 09±6. 78ug/g and 22. 63±11. 08ug/g. Conclusion: Single -dose ceftriaxone 2 g which is injected intravenously during the induction of anaesthesia can supply efficacious drug concentrations in patients blood and tissues.