中老年骨质疏松与下肢动脉粥样硬化相关性分析

Correlation between osteoporosis and arteriosclerosis of lower extremity in middle-aged and elderly people

目的探讨中老年骨质疏松与下肢动脉粥样硬化的相关性。方法 110例中老年患者行骨密度及下肢动脉彩超等检查,根据患者骨密度值分为骨量正常组43例,骨量减少组42例,骨质疏松组25例,比较3组收缩压、舒张压、血清白蛋白、血钙、血肌酐、血脂、血尿酸、空腹血糖及动脉粥样硬化积分(Crouse积分)差异;根据Crouse积分将患者分为无动脉粥样硬化组40例,轻度动脉粥样硬化组48例及中重度动脉粥样硬化组22例,比较各组间腰椎骨密度T值及左髋关节骨密度T值差异;分析骨密度T值与Crouse积分相关性。结果骨质疏松组空腹血糖[(6.52±2.97)mmol/L]高于骨量正常组[(5.56±1.11)mmol/L](P<0.05);骨质疏松组Crouse积分[(14.00±9.00)分]高于骨量正常组[(8.00±5.00)分]和骨量减少组[(8.00±7.00)分](P<0.05);不同骨密度组间收缩压、舒张压、血清白蛋白、血钙、血肌酐、血脂、血尿酸比较差异均无统计学意义(P>0.05);中重度动脉粥样硬化组腰椎骨密度T值(-1.90±0.71)低于轻度动脉粥样硬化组(-0.98±0.57)(P<0.05),中重度动脉粥样硬化组左髋关节骨密度T值(-1.28±0.35)低于无动脉粥样硬化组(-0.40±0.17)及轻度动脉粥样硬化组(-0.63±0.22),差异均有统计学意义(P<0.05);骨密度T值与Crouse积分呈负相关(r=-0.218,P=0.022)。结论中老年人群Crouse积分越高,提示骨密度越低。

Objective To investigate the correlation of osteoporosis with arteriosclerosis of lower extremity in middle- aged and elderly patients. Methods A total of 110 patients received bone mineral density （BMD） detection and lower extremity artery color Doppler imaging examination, and were divided into normal bone mass group （n= 43）, decreased bone mass group （n = 42） and osteoporosis group （n = 25） according to BMD values. The systolic blood pressure, diastolic blood pressure, serum albumin, blood calcium, serum creatinine, blood lipid, blood uric acid, fasting plasma glucose and Crouse integral were compared among three groups. And according to Crouse integral, 110 patients were divided into no-arteriosclerosis group （n = 40）, mild arteriosclerosis group （n = 48）, and moderate and severe arteriosclerosis group （n=22）. The T value of BMD of lumbar vertebrae and T value of BMD of left hip joint were compared among three groups, and the correlation of T value of BMD with Crouse integral was analyzed. Results The fasting plasma glucose was significantly higher in osteoporosis group （（6.52 ±2.97） mmol/L） than that in normal bone mass group （（5. 56±1. 11） mmol/L） （P〈0.05）. The Crouse integral in osteoporosis group （14. 00±9. 00） was significantly higher than that in normal bone mass group （8.00±5.00） and decreased bone mass group （8.00±7.00） （P〈0.05）. There were no significant differences in the systolic blood pressure, diastolic blood pressure, serum albumin, blood calcium, serum creatinine, blood lipid and blood uric acid among three groups （P〉0.05）. T value of BMD of the lumbar vertebrae in moderate and severe arteriosclerosis group （-1.90±0.71） was significantly lower than that in mild arteriosclerosis group （-0. 98±0. 57） （P〈0.05）. T value of BMD of the left hip joint was significantly lower in moderate and severe arteriosclerosis group （-1. 28±0.35） than that in no-arteriosclerosis group （-0.40±0.17） and mile arteriosclerosis group （-0. 63 ± 0. 22） （P〈0.05）. BMD was negatively correlated with the Crouse integral （r=-0. 218, P=0. 022）. Conclusion The higher the Crouse integral is, the lower the BMD gets in middle-aged and elderly people.