摘要
目的探讨尿道内尖锐湿疣患者行光动力治疗前V1服布洛芬缓释胶囊对治疗疼痛的缓解作用。方法153例尿道内尖锐湿疣患者随机分为观察组78例和对照组75例,2组均给予5-盐酸氨酮戊酸-光动力疗法(5-aminolevulinic acid—photodynamic therapy,ALA—PDT)治疗,每次照射20min,每7-10d重复1次,共治疗3次;观察组在每次ALA—PDT治疗前30min口服布洛芬缓释胶囊0.3g。分别于光照5min及治疗完成后30rain行线性视觉模拟评分(visualanalogscale,VAS);于治疗完成后2周评估疣体完全清除率,6个月评估复发率,并进行比较。结果观察组、对照组疣体完全清除率分别为85.9%和84.0%,复发率分别为14.9%和12.5%,2组比较差异均无统计学意义(P〉0.05);治疗5min及治疗完成后30min观察组VAs评分(4.55±1.07、2.09±0.74)均低于对照组(5.57±1.08、3.32±0.97),差异有统计学意义(P〈0.05)。结论尿道内尖锐湿疣患者行ALA—PDT治疗前30min口服布洛芬缓释胶囊可缓解ALA-PDT治疗疼痛,且不影响治疗效果。
Objective To observe the therapeutic effect of preoperative oral administration of ibuprofen sustained release capsule on relieving pain caused by photodynamic therapy for urethral condyloma acuminatum. Methods A total of 153 patients with urethral condyloma acuminatum were randomly divided into observation group (n = 78) and control group (n= 75). Both groups received 5-aminolaevulinic acid-induced photodynamic therapy (ALA-PDT) for 20 rain, once every 7 to 10 days, totally for 3 times. Observation group received oral administration of 0. 3 g ibuprofen sustained release capsule 30 minutes before ALA-PDT. The pain scores were evaluated by using visual analog scale (VAS) after 5-rain radiation and in 30 min after radiation. The clearance rate in 2 weeks after treatment and recurrence rate in 6 months after treatment were evaluated and compared between two groups. Results There were no significant differences in the clearance rates and the recurrence rates between observation group (85. 9%, 14. 9%) and control group (84. 0%, 12.5%) (P〉0.05). The VAS after 5-rain treatment and in 30 rain after treatment were significantly lower in observation group (4.55±1.07, 2.09±0.74) than those in control group (5. 57±1.08, 3. 32±0.97) (P〈0.05). Conelusion Oral administration of ibuprofen sustained release capsule in 30 min before operation may help to relieve pain caused by ALA-PDT for urethral condyloma acuminatum without reducing the therapeutic effect of ALA-PDT.
出处
《中华实用诊断与治疗杂志》
2016年第5期517-518,共2页
Journal of Chinese Practical Diagnosis and Therapy
基金
深圳市卫生计生系统科研项目(201401025)
深圳市卫生计生系统科研项目(201501022)