布洛芬缓释胶囊缓解尿道内尖锐湿疣患者光动力治疗疼痛效果观察被引量：10

Effect of oral ibuprofen sustained release capsule on relieving pain induced by photodynamic therapy for urethral condyloma acuminatum

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摘要目的探讨尿道内尖锐湿疣患者行光动力治疗前V1服布洛芬缓释胶囊对治疗疼痛的缓解作用。方法153例尿道内尖锐湿疣患者随机分为观察组78例和对照组75例，2组均给予5-盐酸氨酮戊酸-光动力疗法（5-aminolevulinic acid—photodynamic therapy，ALA—PDT）治疗，每次照射20min，每7-10d重复1次，共治疗3次；观察组在每次ALA—PDT治疗前30min口服布洛芬缓释胶囊0.3g。分别于光照5min及治疗完成后30rain行线性视觉模拟评分（visualanalogscale，VAS）；于治疗完成后2周评估疣体完全清除率，6个月评估复发率，并进行比较。结果观察组、对照组疣体完全清除率分别为85．9％和84．0％，复发率分别为14．9％和12．5％，2组比较差异均无统计学意义（P〉0．05）；治疗5min及治疗完成后30min观察组VAs评分（4．55±1．07、2.09±0．74）均低于对照组（5．57±1．08、3．32±0．97），差异有统计学意义（P〈0.05）。结论尿道内尖锐湿疣患者行ALA—PDT治疗前30min口服布洛芬缓释胶囊可缓解ALA-PDT治疗疼痛，且不影响治疗效果。 Objective To observe the therapeutic effect of preoperative oral administration of ibuprofen sustained release capsule on relieving pain caused by photodynamic therapy for urethral condyloma acuminatum. Methods A total of 153 patients with urethral condyloma acuminatum were randomly divided into observation group （n = 78） and control group （n= 75）. Both groups received 5-aminolaevulinic acid-induced photodynamic therapy （ALA-PDT） for 20 rain, once every 7 to 10 days, totally for 3 times. Observation group received oral administration of 0. 3 g ibuprofen sustained release capsule 30 minutes before ALA-PDT. The pain scores were evaluated by using visual analog scale （VAS） after 5-rain radiation and in 30 min after radiation. The clearance rate in 2 weeks after treatment and recurrence rate in 6 months after treatment were evaluated and compared between two groups. Results There were no significant differences in the clearance rates and the recurrence rates between observation group （85. 9%, 14. 9%） and control group （84. 0%, 12.5%）（P〉0.05）. The VAS after 5-rain treatment and in 30 rain after treatment were significantly lower in observation group （4.55±1.07, 2.09±0.74） than those in control group （5. 57±1.08, 3. 32±0.97）（P〈0.05）. Conelusion Oral administration of ibuprofen sustained release capsule in 30 min before operation may help to relieve pain caused by ALA-PDT for urethral condyloma acuminatum without reducing the therapeutic effect of ALA-PDT.

作者黄国新叶庭路陈办成王燕邹彦芬

机构地区北京大学深圳医院皮肤科

出处《中华实用诊断与治疗杂志》 2016年第5期517-518,共2页 Journal of Chinese Practical Diagnosis and Therapy

基金深圳市卫生计生系统科研项目(201401025) 深圳市卫生计生系统科研项目(201501022)

关键词尿道内尖锐湿疣布洛芬 5-盐酸氨酮戊酸-光动力疗法疼痛 Urethral condyloma acuminatum ibuprofen 5-aminolaevulinic acid-photodynamic therapy pain

分类号 R752.53 [医药卫生—皮肤病学与性病学]

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